The Effects of a Lipid-Based Nutrient Supplement and Antiretroviral Therapy in a Randomized Controlled Trial on Iron, Copper, and Zinc in Milk from HIV-Infected Malawian Mothers and Associations with Maternal and Infant Biomarkers

Hampel, Daniela; Shahab-Ferdows, Setareh; Gertz, Erik; Flax, Valerie L.; Adair, Linda S.; Bentley, Margaret E.; Jamieson, Denise J.; Tegha, Gerald; Chasela, Charles S.; Kamwendo, Debbie; van der Horst, Charles M.; & Allen, Lindsay H. (Forthcoming). The Effects of a Lipid-Based Nutrient Supplement and Antiretroviral Therapy in a Randomized Controlled Trial on Iron, Copper, and Zinc in Milk from HIV-Infected Malawian Mothers and Associations with Maternal and Infant Biomarkers. Maternal & Child Nutrition.

Hampel, Daniela; Shahab-Ferdows, Setareh; Gertz, Erik; Flax, Valerie L.; Adair, Linda S.; Bentley, Margaret E.; Jamieson, Denise J.; Tegha, Gerald; Chasela, Charles S.; Kamwendo, Debbie; van der Horst, Charles M.; & Allen, Lindsay H. (Forthcoming). The Effects of a Lipid-Based Nutrient Supplement and Antiretroviral Therapy in a Randomized Controlled Trial on Iron, Copper, and Zinc in Milk from HIV-Infected Malawian Mothers and Associations with Maternal and Infant Biomarkers. Maternal & Child Nutrition.

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We evaluated effects of antiretroviral (ARV) therapy and lipid-based nutrient supplements (LNSs) on iron, copper, and zinc in milk of exclusively breastfeeding HIV-infected Malawian mothers and their correlations with maternal and infant biomarkers. Human milk and blood at 2, 6, and 24 weeks post-partum and blood during pregnancy (<50% of iron concentrations met the current adequate intake for infants at 2 weeks and only 1-19% at 24 weeks. Pregnancy haemoglobin was negatively correlated with milk iron at 2 and 6 weeks (r = -.18, p < .02 for both). The associations of the milk minerals with each other were the strongest correlations observed (r = .11-.47, p < .05 for all); none were found with infant biomarkers. At 2 weeks, moderately anaemic women produced milk higher in iron when ferritin was higher or TfR lower. At 6 weeks, higher maternal alpha-1-acid glycoprotein and C-reactive protein were associated with higher milk minerals in mildly anaemic women. Infant TfR was lower when milk mineral concentrations were higher at 6 weeks and when mothers were moderately anaemic during pregnancy. ARV affects copper and zinc milk concentrations in early lactation, and maternal haemoglobin during pregnancy and lactation could influence the association between milk minerals and maternal and infant iron status and biomarkers of inflammation.



JOUR



Hampel, Daniela
Shahab-Ferdows, Setareh
Gertz, Erik
Flax, Valerie L.
Adair, Linda S.
Bentley, Margaret E.
Jamieson, Denise J.
Tegha, Gerald
Chasela, Charles S.
Kamwendo, Debbie
van der Horst, Charles M.
Allen, Lindsay H.



Forthcoming


Maternal & Child Nutrition













10574

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