Genomic Assortative Mating in Marriages in the United States

Guo, Guang; Wang, Lin; Liu, Hexuan; & Randall, Thomas. (2014). Genomic Assortative Mating in Marriages in the United States. PLOS ONE, 9(11), e112322. PMCID: PMC4226554

Guo, Guang; Wang, Lin; Liu, Hexuan; & Randall, Thomas. (2014). Genomic Assortative Mating in Marriages in the United States. PLOS ONE, 9(11), e112322. PMCID: PMC4226554

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Assortative mating in phenotype in human marriages has been widely observed. Using genome-wide genotype data from the Framingham Heart study (FHS; number of married couples = 989) and Health Retirement Survey (HRS; number of married couples = 3,474), this study investigates genomic assortative mating in human marriages. Two types of genomic marital correlations are calculated. The first is a correlation specific to a single married couple “averaged” over all available autosomal single-nucleotide polymorphism (SNPs). In FHS, the average married-couple correlation is 0.0018 with p = 3×10−5; in HRS, it is 0.0017 with p = 7.13×10−13. The marital correlation among the positively assorting SNPs is 0.001 (p = .0043) in FHS and 0.015 (p = 1.66×10−24) in HRS. The sizes of these estimates in FHS and HRS are consistent with what are suggested by the distribution of the allelic combination. The study also estimated SNP-specific correlation “averaged” over all married couples. Suggestive evidence is reported. Future studies need to consider a more general form of genomic assortment, in which different allelic forms in homologous genes and non-homologous genes result in the same phenotype.


Biological and Social Interactions
1A
2a


JOUR



Guo, Guang
Wang, Lin
Liu, Hexuan
Randall, Thomas



2014


PLOS ONE

9

11

e112322








PMC4226554


8707

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