Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure

Laine, Jessica E.; Bailey, Kathryn A.; Olshan, Andrew F.; Smeester, Lisa; Drobna, Zuzana; Styblo, Miroslav; Douillet, Christelle; Garcia-Vargas, Gonzalo; Rubio-Andrade, Marisela; Pathmasiri, Wimal; McRitchie, Susan; Sumner, Susan J.; & Fry, Rebecca C. (2017). Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure. Environmental Science & Technology, 51(1), 625-33. PMCID: PMC5460981

Laine, Jessica E.; Bailey, Kathryn A.; Olshan, Andrew F.; Smeester, Lisa; Drobna, Zuzana; Styblo, Miroslav; Douillet, Christelle; Garcia-Vargas, Gonzalo; Rubio-Andrade, Marisela; Pathmasiri, Wimal; McRitchie, Susan; Sumner, Susan J.; & Fry, Rebecca C. (2017). Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure. Environmental Science & Technology, 51(1), 625-33. PMCID: PMC5460981

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Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gomez Palacio, Mexico. Through multivariable linear regression, ten cord serum metabolites were identified as significantly associated with total urinary iAs and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs). A total of 17 metabolites were identified as significantly associated with total iAs and/or iAs metabolites in cord serum. These metabolites are indicative of changes in important biochemical pathways such as vitamin metabolism, the citric acid (TCA) cycle, and amino acid metabolism. These data highlight that maternal biotransformation of iAs and neonatal levels of iAs and its metabolites are associated with differences in neonate cord metabolomic profiles. The results demonstrate the potential utility of metabolites as biomarkers/indicators of in utero environmental exposure.




JOUR



Laine, Jessica E.
Bailey, Kathryn A.
Olshan, Andrew F.
Smeester, Lisa
Drobna, Zuzana
Styblo, Miroslav
Douillet, Christelle
Garcia-Vargas, Gonzalo
Rubio-Andrade, Marisela
Pathmasiri, Wimal
McRitchie, Susan
Sumner, Susan J.
Fry, Rebecca C.



2017


Environmental Science & Technology

51

1

625-33








PMC5460981


9894

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