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Genome-Wide Association Meta-Analysis Identifies Novel Variants Associated with Fasting Plasma Glucose in East Asians

Hwang, Joo-Yeon; Sim, Xueling; Wu, Ying; Liang, Jun; Tabara, Yasuharu; Hu, Cheng; Hara, Kazuo; Tam, Claudia H.T.; Cai, Qiuyin; Zhao, Qi; Jee, Sunha; Takeuchi, Fumihiko; Go, Min Jin; Ong, Rick Twee Hee; Ohkubo, Takayoshi; Kim, Young Jin; Zhang, Rong; Yamauchi, Toshimasa; So, Wing Yee; Long, Jirong; Gu, Dongfeng; Lee, Nanette R.; Kim, Soriul; Katsuya, Tomohiro; Oh, Ji Hee; Liu, Jianjun; Umemura, Satoshi; Kim, Yeon-Jung; Jiang, Feng; Maeda, Shiro; Chan, Juliana C.N.; Lu, Wei; Hixson, James E.; Adair, Linda S.; Jung, Keum Ji; Nabika, Toru; Bae, Jae-Bum; Lee, Mi Hee; Seielstad, Mark; Young, Terri L.; Teo, Yik Ying; Kita, Yoshikuni; Takashima, Naoyuki; Osawa, Haruhiko; Lee, So-Hyun; Shin, Min-Ho; Shin, Dong Hoon; Choi, Bo Youl; Shi, Jiajun; Gao, Yu-Tang; Xiang, Yong-Bing; Zheng, Wei; Kato, Norihiro; Yoon, Miwuk; He, Jiang; Shu, Xiao Ou; Ma, Ronald C.W.; Kadowaki, Takashi; Jia, Weiping; Miki, Tetsuro; Qi, Lu; Tai, E. Shyong; Mohlke, Karen L.; Han, Bok-Ghee; Cho, Yoon Shin; & Kim, Bong-Jo. (2015). Genome-Wide Association Meta-Analysis Identifies Novel Variants Associated with Fasting Plasma Glucose in East Asians. Diabetes, 64(1), 291-8.

Hwang, Joo-Yeon; Sim, Xueling; Wu, Ying; Liang, Jun; Tabara, Yasuharu; Hu, Cheng; Hara, Kazuo; Tam, Claudia H.T.; Cai, Qiuyin; Zhao, Qi; Jee, Sunha; Takeuchi, Fumihiko; Go, Min Jin; Ong, Rick Twee Hee; Ohkubo, Takayoshi; Kim, Young Jin; Zhang, Rong; Yamauchi, Toshimasa; So, Wing Yee; Long, Jirong; Gu, Dongfeng; Lee, Nanette R.; Kim, Soriul; Katsuya, Tomohiro; Oh, Ji Hee; Liu, Jianjun; Umemura, Satoshi; Kim, Yeon-Jung; Jiang, Feng; Maeda, Shiro; Chan, Juliana C.N.; Lu, Wei; Hixson, James E.; Adair, Linda S.; Jung, Keum Ji; Nabika, Toru; Bae, Jae-Bum; Lee, Mi Hee; Seielstad, Mark; Young, Terri L.; Teo, Yik Ying; Kita, Yoshikuni; Takashima, Naoyuki; Osawa, Haruhiko; Lee, So-Hyun; Shin, Min-Ho; Shin, Dong Hoon; Choi, Bo Youl; Shi, Jiajun; Gao, Yu-Tang; Xiang, Yong-Bing; Zheng, Wei; Kato, Norihiro; Yoon, Miwuk; He, Jiang; Shu, Xiao Ou; Ma, Ronald C.W.; Kadowaki, Takashi; Jia, Weiping; Miki, Tetsuro; Qi, Lu; Tai, E. Shyong; Mohlke, Karen L.; Han, Bok-Ghee; Cho, Yoon Shin; & Kim, Bong-Jo. (2015). Genome-Wide Association Meta-Analysis Identifies Novel Variants Associated with Fasting Plasma Glucose in East Asians. Diabetes, 64(1), 291-8.

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Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.




JOUR



Hwang, Joo-Yeon
Sim, Xueling
Wu, Ying
Liang, Jun
Tabara, Yasuharu
Hu, Cheng
Hara, Kazuo
Tam, Claudia H.T.
Cai, Qiuyin
Zhao, Qi
Jee, Sunha
Takeuchi, Fumihiko
Go, Min Jin
Ong, Rick Twee Hee
Ohkubo, Takayoshi
Kim, Young Jin
Zhang, Rong
Yamauchi, Toshimasa
So, Wing Yee
Long, Jirong
Gu, Dongfeng
Lee, Nanette R.
Kim, Soriul
Katsuya, Tomohiro
Oh, Ji Hee
Liu, Jianjun
Umemura, Satoshi
Kim, Yeon-Jung
Jiang, Feng
Maeda, Shiro
Chan, Juliana C.N.
Lu, Wei
Hixson, James E.
Adair, Linda S.
Jung, Keum Ji
Nabika, Toru
Bae, Jae-Bum
Lee, Mi Hee
Seielstad, Mark
Young, Terri L.
Teo, Yik Ying
Kita, Yoshikuni
Takashima, Naoyuki
Osawa, Haruhiko
Lee, So-Hyun
Shin, Min-Ho
Shin, Dong Hoon
Choi, Bo Youl
Shi, Jiajun
Gao, Yu-Tang
Xiang, Yong-Bing
Zheng, Wei
Kato, Norihiro
Yoon, Miwuk
He, Jiang
Shu, Xiao Ou
Ma, Ronald C.W.
Kadowaki, Takashi
Jia, Weiping
Miki, Tetsuro
Qi, Lu
Tai, E. Shyong
Mohlke, Karen L.
Han, Bok-Ghee
Cho, Yoon Shin
Kim, Bong-Jo



2015


Diabetes

64

1

291-8







10.2337/db14-0563



220