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Inflammatory Profiles in the Non-Pregnant State Predict Offspring Birth Weight at Cebu: Evidence for Inter-Generational Effects of Low Grade Inflammation

Kuzawa, Christopher W.; Tallman, Paula Skye; Adair, Linda S.; Lee, Nanette R.; & McDade, Thomas W. (2012). Inflammatory Profiles in the Non-Pregnant State Predict Offspring Birth Weight at Cebu: Evidence for Inter-Generational Effects of Low Grade Inflammation. Annals of Human Biology, 39(4), 267-74. PMCID: PMC3532904

Kuzawa, Christopher W.; Tallman, Paula Skye; Adair, Linda S.; Lee, Nanette R.; & McDade, Thomas W. (2012). Inflammatory Profiles in the Non-Pregnant State Predict Offspring Birth Weight at Cebu: Evidence for Inter-Generational Effects of Low Grade Inflammation. Annals of Human Biology, 39(4), 267-74. PMCID: PMC3532904

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Background: Although maternal infection and inflammation during pregnancy can adversely affect offspring birth weight (BW), whether low grade inflammation in the non-pregnant state predicts BW is unknown. Aim: To evaluate relationships between offspring BW and pro- and anti-inflammatory factors measured in parous but non-pregnant women. Subjects and methods: Data come from 234 parous Filipino females (21.5 ± 0.3 years) in the Cebu Longitudinal Health and Nutrition Survey, a population-based birth cohort in Metropolitan Cebu, Philippines. Pro-inflammatory [Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), tumour necrosis factor alpha (TNFα), C-reactive protein (CRP)] and anti-inflammatory [Interleukin-10 (IL-10)] factors were measured in fasting plasma when the women were not pregnant, and related to recalled offspring BW. Results: BW in female offspring was lower only among women with high IL-1β. Although pro-inflammatory cytokines did not predict BW in male offspring, women with higher anti-inflammatory IL-10 gave birth to larger males. Women with a combination of low inflammatory (IL-6) and high anti-inflammatory (IL-10) factors (interaction p < 0.104) gave birth to the largest males. Conclusion: Immune factors measured outside of pregnancy predict offspring BW in these young women. Stable variation in inflammatory phenotype could impact the gestational environment of offspring, thus pointing to potential inter-generational effects of chronic low-grade inflammation.




JOUR



Kuzawa, Christopher W.
Tallman, Paula Skye
Adair, Linda S.
Lee, Nanette R.
McDade, Thomas W.



2012


Annals of Human Biology

39

4

267-74







10.3109/03014460.2012.692810

PMC3532904


30