Second Trimester Folate Status and Preterm Birth

Siega-Riz, Anna Maria; Savitz, David A.; Zeisel, Steven H.; Thorp, John M., Jr.; & Herring, Amy H. (2004). Second Trimester Folate Status and Preterm Birth. American Journal of Obstetrics and Gynecology, 191(6), 1851-7.

Reference Type:
Journal Article

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Author(s):
Siega-Riz, Anna Maria
Savitz, David A.
Zeisel, Steven H.
Thorp, John M., Jr.
Herring, Amy H.

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Year Published:
2004

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Journal Name:
American Journal of Obstetrics and Gynecology

Volume Number:
191

Issue Number:
6

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1851-7

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Reference ID:
2638

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Abstract:

OBJECTIVE: The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth. STUDY DESIGN: Women were recruited at 24 to 29 weeks' gestation from 1995 to 2000 into the Pregnancy, Infection, and Nutrition Study. Those who completed an interview and a food frequency questionnaire, or provided a blood sample for radioassay of serum (n = 2026) and red blood cell (n = 1034) folate were included. RESULTS: Mean daily dietary folate intake was 463 microg (SD +/- 248). Intake <16.3 ng/mL and red blood cell folate levels </=626.6 ng/mL yielded adjusted risk ratios of 1.8 (95% CI 1.3-2.5) and 1.7 (95% CI 1.1-2.6), respectively. Patterns were similar for spontaneous and overall preterm birth. CONCLUSION: These results support the hypothesis that low folate levels during the second trimester of pregnancy are associated with an increased risk of preterm birth.

Keyword(s):
Biological and Social Interactions

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Citation:

Siega-Riz, Anna Maria; Savitz, David A.; Zeisel, Steven H.; Thorp, John M., Jr.; & Herring, Amy H. (2004). Second Trimester Folate Status and Preterm Birth. American Journal of Obstetrics and Gynecology, 191(6), 1851-7.