Drinking Water Disinfection By-Product Exposure and Fetal Growth
Hoffman, Caroline S.; Mendola, Pauline; Savitz, David A.; Herring, Amy H.; Loomis, Dana P.; Hartmann, Katherine E.; Singer, Philip C.; Weinberg, Howard S.; & Olshan, Andrew F. (2008). Drinking Water Disinfection By-Product Exposure and Fetal Growth. Epidemiology, 19(5), 729-37.
Journal Article
Hoffman, Caroline S.
Mendola, Pauline
Savitz, David A.
Herring, Amy H.
Loomis, Dana P.
Hartmann, Katherine E.
Singer, Philip C.
Weinberg, Howard S.
Olshan, Andrew F.
2008
Epidemiology
19
5
729-37
10.1097/EDE.0b013e3181812bd4
3477
BACKGROUND:: Previous studies suggest that elevated exposure to drinking water disinfection by-products (DBPs)-in particular, total trihalomethanes (TTHMs)-may lead to fetal growth restriction. We examined the effects of exposure to TTHMs, haloacetic acids, and total organic halide on the probability of delivering a small-for-gestational-age (SGA) infant and on birth weight at term. METHODS:: Women early in pregnancy (/=80 mug/L to women with exposure <80 mug/L (risk ratio = 2.0 [95% confidence interval = 1.1-3.6]), but not when examining other exposure contrasts. Bayesian analyses did not support a consistent association between any DBP species and fetal growth, although these analyses were based on small sample sizes. CONCLUSIONS:: Our results do not suggest an adverse effect of haloacetic acid or total organic halide exposure on fetal growth. An association of TTHM with SGA was seen only for average residential concentrations above the current regulatory standard.
Fertility, Families, and Children
Biological and Social Interactions
Place, Space, and Health
3477.ris
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Hoffman, Caroline S.; Mendola, Pauline; Savitz, David A.; Herring, Amy H.; Loomis, Dana P.; Hartmann, Katherine E.; Singer, Philip C.; Weinberg, Howard S.; & Olshan, Andrew F. (2008). Drinking Water Disinfection By-Product Exposure and Fetal Growth. Epidemiology, 19(5), 729-37.
