Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

Filed under: Fertility, Families, and Children

Refuerzo, Jerrie S.; Momirova, Valerija; Peaceman, Alan M.; Sciscione, Anthony; Rouse, Dwight J.; Caritis, Steve N.; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M., Jr.; Sorokin, Yoram; Carpenter, Marshall W.; Lo, Julie; & Harper, Margaret, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (2010). Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term. American Journal of Perinatology, 27(7), 537-42. PMCID: PMC2990398

Reference Type:
Journal Article

Secondary Title:

Series Title:

Author(s):
Refuerzo, Jerrie S.
Momirova, Valerija
Peaceman, Alan M.
Sciscione, Anthony
Rouse, Dwight J.
Caritis, Steve N.
Spong, Catherine Y.
Varner, Michael W.
Malone, Fergal D.
Iams, Jay D.
Mercer, Brian M.
Thorp, John M., Jr.
Sorokin, Yoram
Carpenter, Marshall W.
Lo, Julie
Harper, Margaret, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Editor(s):

Series Author(s):

Year Published:
2010

Date Published:

Journal Name:
American Journal of Perinatology

Volume Number:
27

Issue Number:
7

Start Page Number:
537-42

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Series Volume:

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DOI:
10.1055/s-0030-1248940

PMCID:
PMC2990398

NIHMSID:

Reference ID:
4454

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Abstract:

We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 32 (0)/ (7) and 33 (6)/ (7) weeks and LPTB between 34 (0)/ (7) and 36 (6)/ (7) weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth ( P < 0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.

Keyword(s):
Fertility, Families, and Children

URL:

http://dx.doi.org/10.1055/s-0030-1248940

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Citation:

Refuerzo, Jerrie S.; Momirova, Valerija; Peaceman, Alan M.; Sciscione, Anthony; Rouse, Dwight J.; Caritis, Steve N.; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M., Jr.; Sorokin, Yoram; Carpenter, Marshall W.; Lo, Julie; & Harper, Margaret, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (2010). Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term. American Journal of Perinatology, 27(7), 537-42. PMCID: PMC2990398