Effects of Pre-Pregnancy Body Mass Index and Gestational Weight Gain on Infant Anthropometric Outcomes
Journal Article
Deierlein, Andrea L.
Siega-Riz, Anna Maria
Adair, Linda S.
Herring, Amy H.
2011
20110224
Journal of Pediatrics
158
2
221-6
20100922
10.1016/j.jpeds.2010.08.008
PMC3017634
4571
OBJECTIVE: To determine whether pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) influence infant postnatal growth.
STUDY DESIGN: Participants were from the Pregnancy, Infection, and Nutrition study, a prospective pregnancy cohort. Term infants with weight or length measurements at approximately 6 months were included (n = 363). Multivariable regression estimated associations for weight-for-age (WAZ), length-for-age (LAZ), and weight-for-length z-scores (WLZ) and rapid infant weight gain with categorical maternal exposures defined with the 2009 Institute of Medicine recommendations.
RESULTS: Pre-pregnancy overweight and obesity were associated with higher WAZ (linear regression coefficient [?], 0.32; 95% confidence interval [CI], 0.04-0.61) and WLZ (?, 0.39; 95% CI, 0.02-0.76), respectively. Pre-pregnancy BMI was not associated with LAZ. Excessive GWG was associated with higher WAZ (?, 0.39; 95% CI, 0.15-0.62) and LAZ (?, 0.34; 95% CI, 0.12-0.56). Excessive GWG ?200% of recommended amount was associated with higher WAZ (?, 0.68; 95% CI, 0.28-1.07), LAZ (?, 0.45; 95% CI, 0.06-0.83), and WLZ (?, 0.43; 95% CI, 0.04-0.82). Risk of rapid weight gain increased across maternal exposure categories; however, none of the estimates were significant.
CONCLUSIONS: Pre-pregnancy BMI and GWG are modifiable intrauterine exposures that influence infant postnatal anthropometric outcomes. Further investigation with infant body composition measurements is warranted.
Biological and Social Interactions
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