The Effect of Plurality and Obesity on Betamethasone Concentrations in Women at Risk for Preterm Delivery

Filed under: Fertility, Families, and Children

Gyamfi, Cynthia; Mele, Lisa; Wapner, Ronald J.; Spong, Catherine Y.; Peaceman, Alan M.; Sorokin, Yoram; Dudley, Donald J.; Johnson, Francee; Leveno, Kenneth J.; Caritis, Steve N.; Mercer, Brian M.; Thorp, John M., Jr.; O'Sullivan, Mary Jo; Ramin, Susan M.; Carpenter, Marshall W.; Rouse, Dwight J.; Miodovnik, Menachem; & Sibai, Baha M., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (2010). The Effect of Plurality and Obesity on Betamethasone Concentrations in Women at Risk for Preterm Delivery. American Journal of Obstetrics and Gynecology, 203(3), 219.e1-5. PMCID: PMC3214971

Reference Type:
Journal Article

Secondary Title:

Series Title:

Author(s):
Gyamfi, Cynthia
Mele, Lisa
Wapner, Ronald J.
Spong, Catherine Y.
Peaceman, Alan M.
Sorokin, Yoram
Dudley, Donald J.
Johnson, Francee
Leveno, Kenneth J.
Caritis, Steve N.
Mercer, Brian M.
Thorp, John M., Jr.
O'Sullivan, Mary Jo
Ramin, Susan M.
Carpenter, Marshall W.
Rouse, Dwight J.
Miodovnik, Menachem
Sibai, Baha M., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Editor(s):

Series Author(s):

Year Published:
2010

Date Published:

Journal Name:
American Journal of Obstetrics and Gynecology

Volume Number:
203

Issue Number:
3

Start Page Number:
219.e1-5

End Page Number:

Edition:

Series Volume:

Publisher:

City of Publication:

ISSN/ISBN:

DOI:
10.1016/j.ajog.2010.04.047

PMCID:
PMC3214971

NIHMSID:

Reference ID:
4585

Miscellaneous:

Abstract:

Objective: Antenatal corticosteroids (ACS) decrease respiratory distress syndrome in singleton gestations. Twin data are less clear. Obesity and body mass index (BMI) also affect medication distribution volume. We evaluated whether maternal or neonatal cord betamethasone concentrations differed in twin gestations or obese patients. Study design: Participants receiving betamethasone in a randomized controlled trial of weekly ACS were identified. We analyzed maternal delivery and cord serum betamethasone concentrations comparing singletons with twins and obese (BMI ?30 kg/m2) with nonobese women. Results: Fifty-five maternal and 45 cord blood samples were available. Unadjusted median maternal serum concentrations appeared paradoxically higher in both twin gestations and the obese. However, after controlling for confounders, there were no differences in betamethasone concentrations in maternal serum or cord blood between singletons and twins (P = .61 vs P = .14) or nonobese and obese women (P = .67 vs 0.12). Conclusion: Maternal and umbilical cord blood serum betamethasone concentrations are not different in twin gestations or obese women.

Keyword(s):
Fertility, Families, and Children

URL:

http://dx.doi.org/10.1016/j.ajog.2010.04.047

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Citation:

Gyamfi, Cynthia; Mele, Lisa; Wapner, Ronald J.; Spong, Catherine Y.; Peaceman, Alan M.; Sorokin, Yoram; Dudley, Donald J.; Johnson, Francee; Leveno, Kenneth J.; Caritis, Steve N.; Mercer, Brian M.; Thorp, John M., Jr.; O'Sullivan, Mary Jo; Ramin, Susan M.; Carpenter, Marshall W.; Rouse, Dwight J.; Miodovnik, Menachem; & Sibai, Baha M., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (2010). The Effect of Plurality and Obesity on Betamethasone Concentrations in Women at Risk for Preterm Delivery. American Journal of Obstetrics and Gynecology, 203(3), 219.e1-5. PMCID: PMC3214971