Periconceptional Intake of Folic Acid and Food Folate and Risks of Preterm Delivery

Reference Type:
Journal Article

Secondary Title:

Series Title:

Author(s):
Shaw, Gary M.
Carmichael, Suzan L.
Yang, Wei
Siega-Riz, Anna Maria, and the National Birth Defects Prevention Study

Editor(s):

Series Author(s):

Year Published:
2011

Date Published:

Journal Name:
American Journal of Perinatology

Volume Number:
28

Issue Number:
10

Start Page Number:
747-51

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Edition:

Series Volume:

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ISSN/ISBN:

DOI:
10.1055/s-0031-1280855

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Reference ID:
5005

Miscellaneous:

Abstract:

We investigated multiple sources of folate and folic acid to determine whether their periconceptional intakes were associated with preterm delivery. Studied were controls from the National Birth Defects Prevention Study delivered September 1998 to December 2005. Telephone interviews were conducted with 5952 (68% of eligible) mothers. Women were queried about intake of vitamin supplements in the 12 weeks before conception through delivery. A version of the Nurse's Health Study food frequency questionnaire was used to assess food sources. Eight percent of infants ( N = 487) were preterm (<37 weeks). Compared with women who began intake of supplements with folic acid before pregnancy, those who began any time during pregnancy had an ~20% lowered risk of preterm delivery. Lower dietary intakes showed a modest increased risk of preterm delivery: odds ratios were 1.44 (1.01 to 2.04) for lowest quartile intake of folate and 1.27 (0.95 to 1.69) for lowest quartile intake of folic acid compared with the highest. Findings suggest some evidence that folates influenced risks; however, an interpretation of results was also consistent with no association between intake of folates and preterm delivery.

Keyword(s):
Fertility, Families, and Children

URL:

http://dx.doi.org/10.1055/s-0031-1280855

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Citation:

Shaw, Gary M.; Carmichael, Suzan L.; Yang, Wei; & Siega-Riz, Anna Maria, and the National Birth Defects Prevention Study. (2011). Periconceptional Intake of Folic Acid and Food Folate and Risks of Preterm Delivery. American Journal of Perinatology, 28(10), 747-51.