Vitamin or Mineral Supplement Intake and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium
Journal Article
Li, Qian
Chuang, Shu-Chun
Eluf-Neto, Jose
Menezes, Ana
Matos, Elena
Koifman, Sergio
Wünsch-Filho, Victor
Fernandez, Leticia
Daudt, Alexander W.
Curado, Maria Paula
Winn, Deborah M.
Franceschi, Silvia
Herrero, Rolando
Castellsague, Xavier
Morgenstern, Hal
Zhang, Zuo-Feng
Lazarus, Philip
Muscat, Joshua
McClean, Michael
Kelsey, Karl T.
Hayes, Richard B.
Purdue, Mark P.
Schwartz, Stephen M.
Chen, Chu
Benhamou, Simone
Olshan, Andrew F.
Yu, Guopei
Schantz, Stimson
Ferro, Gilles
Brennan, Paul
Boffetta, Paolo
Hashibe, Mia
2012
International Journal of Cancer
131
7
1686-99
10.1002/ijc.27405
PMC3376697
5172
To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, and 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium, and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, and pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR=0.76, 95% CI=0.59-0.96) and with ever use of calcium supplement (OR=0.64, 95% CI=0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR=0.72, 95% CI=0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR=0.36, 95% CI=0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of head and neck cancer.
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