Relationship between 17-Hydroxyprogesterone Caproate Concentrations and Gestational Age at Delivery in Twin Gestation

Caritis, Steve N.; Simhan, Hyagriv N.; Zhao, Yuan; Rouse, Dwight J.; Peaceman, Alan M.; Sciscione, Anthony; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M., Jr.; Sorokin, Yoram; Carpenter, Marshall; Lo, Julie; Ramin, Susan M.; & Harper, Margaret. (Forthcoming). Relationship between 17-Hydroxyprogesterone Caproate Concentrations and Gestational Age at Delivery in Twin Gestation. American Journal of Obstetrics and Gynecology. PMCID: PMC Journal - In Process

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Journal Article

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Author(s):
Caritis, Steve N.
Simhan, Hyagriv N.
Zhao, Yuan
Rouse, Dwight J.
Peaceman, Alan M.
Sciscione, Anthony
Spong, Catherine Y.
Varner, Michael W.
Malone, Fergal D.
Iams, Jay D.
Mercer, Brian M.
Thorp, John M., Jr.
Sorokin, Yoram
Carpenter, Marshall
Lo, Julie
Ramin, Susan M.
Harper, Margaret

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Forthcoming

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American Journal of Obstetrics and Gynecology

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DOI:
10.1016/j.ajog.2012.08.001

PMCID:
PMC Journal - In Process

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Reference ID:
5498

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Abstract:

Objective We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action. Study design Blood was obtained between 24-28 weeks (epoch 1) and 32-35 weeks (epoch 2) in 217 women with twin gestation receiving 17-OHPC or placebo. Gestational age at delivery and concentrations of 17-OHPC, 17-hydroxyprogesterone, progesterone, C-reactive protein (CRP), and corticotrophin-releasing hormone were assessed. Results Women with higher concentrations of 17-OHPC delivered at earlier gestational ages than women with lower concentrations (P < .001). Women receiving 17-OHPC demonstrated significantly higher (P = .005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups. A highly significant (P < .0001) positive relationship was observed between 17-OHPC concentration and progesterone and 17-hydroxyprogesterone concentrations at both epochs. Corticotropin-releasing hormone concentrations did not differ by treatment group. Conclusion 17-OHPC may adversely impact gestational age at delivery in women with twin gestation.

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http://dx.doi.org/10.1016/j.ajog.2012.08.001

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Caritis, Steve N.; Simhan, Hyagriv N.; Zhao, Yuan; Rouse, Dwight J.; Peaceman, Alan M.; Sciscione, Anthony; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M., Jr.; Sorokin, Yoram; Carpenter, Marshall; Lo, Julie; Ramin, Susan M.; & Harper, Margaret. (Forthcoming). Relationship between 17-Hydroxyprogesterone Caproate Concentrations and Gestational Age at Delivery in Twin Gestation. American Journal of Obstetrics and Gynecology. PMCID: PMC Journal - In Process