A Large-Scale Multi-Ancestry Genome-Wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Sung, Yun J.; Winkler, Thomas W.; de Las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A.; Noordam, Raymond; Aslibekyan, Stella; Aschard, Hugues; Bartz, Traci M.; Dorajoo, Rajkumar; Liu, Yongmei; Manning, Alisa K.; Rankinen, Tuomo; Smith, Albert Vernon; Tajuddin, Salman M.; Tayo, Bamidele O.; Warren, Helen R.; Zhao, Wei; Zhou, Yanhua; Matoba, Nana; Sofer, Tamar; Alver, Maris; Amini, Marzyeh; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Gandin, Ilaria; Gao, Chuan; Giulianini, Franco; Goel, Anuj; Harris, Sarah E.; Hartwig, Fernando Pires; Horimoto, Andrea R. V. R.; Hsu, Fang-Chi; Jackson, Anne U.; Kahonen, Mika; Kasturiratne, Anuradhani; Kuhnel, Brigitte; Leander, Karin; Lee, Wen-Jane; Lin, Keng-Hung; Luan, Jian 'an; McKenzie, Colin A.; Meian, He; Nelson, Christopher P.; Rauramaa, Rainer; Schupf, Nicole; Scott, Robert A.; Sheu, Wayne H. H.; Stancakova, Alena; Takeuchi, Fumihiko; van der Most, Peter J.; Varga, Tibor V.; Wang, Heming; Wang, Yajuan; Ware, Erin B.; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R.; Zhang, Weihua; Zhao, Jing Hua; Afaq, Saima; Alfred, Tamuno; Amin, Najaf; Arking, Dan; Aung, Tin; Barr, R. Graham; Bielak, Lawrence F.; Boerwinkle, Eric A.; Bottinger, Erwin P.; Braund, Peter S.; Brody, Jennifer A.; Broeckel, Ulrich; Cabrera, Claudia P.; Cade, Brian; Caizheng, Yu; Campbell, Archie; Canouil, Mickael; Chakravarti, Aravinda; CHARGE Neurology Working Group; Chauhan, Ganesh; Christensen, Kaare; Cocca, Massimiliano; COGENT-Kidney Consortium; Collins, Francis S.; Connell, John M.; de Mutsert, Renee; de Silva, H. Janaka; Debette, Stephanie; Dorr, Marcus; Duan, Qing; Eaton, Charles B.; Ehret, Georg; Evangelou, Evangelos; Faul, Jessica D.; Fisher, Virginia A.; Forouhi, Nita G.; Franco, Oscar H.; Friedlander, Yechiel; Gao, He; GIANT Consortium; Gigante, Bruna; Graff, Mariaelisa; Gu, C. Charles; Gu, Dongfeng; Gupta, Preeti; Hagenaars, Saskia P.; Harris, Tamara B.; He, Jiang; Heikkinen, Sami; Heng, Chew-Kiat; Hirata, Makoto; Hofman, Albert; Howard, Barbara V.; Hunt, Steven; Irvin, Marguerite Ryan; Jia, Yucheng; Joehanes, Roby; Justice, Anne E.; Katsuya, Tomohiro; Kaufman, Joel; Kerrison, Nicola D.; Khor, Chiea Chuen; Koh, Woon-Puay; Koistinen, Heikki A.; Komulainen, Pirjo; Kooperberg, Charles L.; Krieger, Jose E.; Kubo, Michiaki; Kuusisto, Johanna; Langefeld, Carl D.; Langenberg, Claudia; Launer, Lenore J.; Lehne, Benjamin; Lewis, Cora E.; Li, Yize; Lifelines Cohort Study; Lim, Sing Hui; Lin, Shiow; Liu, Ching-Ti; Liu, Jianjun; Liu, Jingmin; Liu, Kiang; Liu, Yeheng; Loh, Marie; Lohman, Kurt K.; Long, Jirong; Louie, Tin; Magi, Reedik; Mahajan, Anubha; Meitinger, Thomas; Metspalu, Andres; Milani, Lili; Momozawa, Yukihide; Morris, Andrew P.; Mosley, Thomas H. Jr.; Munson, Peter; Murray, Alison D.; Nalls, Mike A; Nasri, Ubaydah; Norris, Jill M.; North, Kari E.; Ogunniyi, Adesola; Padmanabhan, Sandosh; Palmas, Walter R.; Palmer, Nicholette D.; Pankow, James S.; Pedersen, Nancy L.; Peters, Annette; Peyser, Patricia A.; Polasek, Ozren; Raitakari, Olli T.; Renstrom, Frida; Rice, Treva K.; Ridker, Paul M.; Robino, Antonietta; Robinson, Jennifer G.; Rose, Lynda M.; Rudan, Igor; Sabanayagam, Charumathi; Salako, Babatunde L.; Sandow, Kevin; Schmidt, Carsten O.; Schreiner, Pamela J.; Scott, William R.; Seshadri, Sudha; Sever, Peter; Sitlani, Colleen M.; Smith, Jennifer A.; Snieder, Harold; Starr, John M.; Strauch, Konstantin; Tang, Hua; Taylor, Kent D.; Teo, Yik Ying; Tham, Yih Chung; Uitterlinden, Andre G.; Waldenberger, Melanie; Wang, Lihua; Wang, Ya X.; Wei, Wen Bin; Williams, Christine; Wilson, Gregory; Wojczynski, Mary K.; Yao, Jie; Yuan, Jian-Min; Zonderman, Alan B.; Becker, Diane M.; Boehnke, Michael; Bowden, Donald W.; Chambers, John C.; Chen, Yii-Der Ida; de Faire, Ulf; Deary, Ian J.; Esko, Tonu; Farrall, Martin; Forrester, Terrence; Franks, Paul W.; Freedman, Barry I.; Froguel, Philippe; Gasparini, Paolo; Gieger, Christian; Horta, Bernardo Lessa; Hung, Yi-Jen; Jonas, Jost B.; Kato, Norihiro; Kooner, Jaspal S.; Laakso, Markku; Lehtimaki, Terho; Liang, Kae-Woei; Magnusson, Patrik K. E.; Newman, Anne B.; Oldehinkel, Albertine J.; Pereira, Alexandre C.; Redline, Susan; Rettig, Rainer; Samani, Nilesh J.; Scott, James; Shu, Xiao-Ou; van der Harst, Pim; Wagenknecht, Lynne E.; Wareham, Nicholas J.; Watkins, Hugh; Weir, David R.; Wickremasinghe, Ananda R.; Wu, Tangchun; Zheng, Wei; Kamatani, Yoichiro; Laurie, Cathy C.; Bouchard, Claude; Cooper, Richard S.; Evans, Michele K.; Gudnason, Vilmundur; Kardia, Sharon L. R.; Kritchevsky, Stephen B.; Levy, Daniel; O'Connell, Jeff R.; Psaty, Bruce M.; van Dam, Rob M.; Sims, Mario; Arnett, Donna K.; Mook-Kanamori, Dennis O.; Kelly, Tanika N.; Fox, Ervin R.; Hayward, Caroline; Fornage, Myriam; Rotimi, Charles N.; Province, Michael A.; van Duijn, Cornelia M.; Tai, E. Shyong; Wong, Tien Yin; Loos, Ruth J. F.; Reiner, Alex P.; Rotter, Jerome I.; Zhu, Xiaofeng; Bierut, Laura J.; Gauderman, W. James; Caulfield, Mark J.; Elliott, Paul; Rice, Kenneth; Munroe, Patricia B.; Morrison, Alanna C.; Cupples, L. Adrienne; Rao, Dabeeru C.; & Chasman, Daniel I. (2018). A Large-Scale Multi-Ancestry Genome-Wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102(3), 375-400. PMCID: PMC5985266

Sung, Yun J.; Winkler, Thomas W.; de Las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A.; Noordam, Raymond; Aslibekyan, Stella; Aschard, Hugues; Bartz, Traci M.; Dorajoo, Rajkumar; Liu, Yongmei; Manning, Alisa K.; Rankinen, Tuomo; Smith, Albert Vernon; Tajuddin, Salman M.; Tayo, Bamidele O.; Warren, Helen R.; Zhao, Wei; Zhou, Yanhua; Matoba, Nana; Sofer, Tamar; Alver, Maris; Amini, Marzyeh; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Gandin, Ilaria; Gao, Chuan; Giulianini, Franco; Goel, Anuj; Harris, Sarah E.; Hartwig, Fernando Pires; Horimoto, Andrea R. V. R.; Hsu, Fang-Chi; Jackson, Anne U.; Kahonen, Mika; Kasturiratne, Anuradhani; Kuhnel, Brigitte; Leander, Karin; Lee, Wen-Jane; Lin, Keng-Hung; Luan, Jian 'an; McKenzie, Colin A.; Meian, He; Nelson, Christopher P.; Rauramaa, Rainer; Schupf, Nicole; Scott, Robert A.; Sheu, Wayne H. H.; Stancakova, Alena; Takeuchi, Fumihiko; van der Most, Peter J.; Varga, Tibor V.; Wang, Heming; Wang, Yajuan; Ware, Erin B.; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R.; Zhang, Weihua; Zhao, Jing Hua; Afaq, Saima; Alfred, Tamuno; Amin, Najaf; Arking, Dan; Aung, Tin; Barr, R. Graham; Bielak, Lawrence F.; Boerwinkle, Eric A.; Bottinger, Erwin P.; Braund, Peter S.; Brody, Jennifer A.; Broeckel, Ulrich; Cabrera, Claudia P.; Cade, Brian; Caizheng, Yu; Campbell, Archie; Canouil, Mickael; Chakravarti, Aravinda; CHARGE Neurology Working Group; Chauhan, Ganesh; Christensen, Kaare; Cocca, Massimiliano; COGENT-Kidney Consortium; Collins, Francis S.; Connell, John M.; de Mutsert, Renee; de Silva, H. Janaka; Debette, Stephanie; Dorr, Marcus; Duan, Qing; Eaton, Charles B.; Ehret, Georg; Evangelou, Evangelos; Faul, Jessica D.; Fisher, Virginia A.; Forouhi, Nita G.; Franco, Oscar H.; Friedlander, Yechiel; Gao, He; GIANT Consortium; Gigante, Bruna; Graff, Mariaelisa; Gu, C. Charles; Gu, Dongfeng; Gupta, Preeti; Hagenaars, Saskia P.; Harris, Tamara B.; He, Jiang; Heikkinen, Sami; Heng, Chew-Kiat; Hirata, Makoto; Hofman, Albert; Howard, Barbara V.; Hunt, Steven; Irvin, Marguerite Ryan; Jia, Yucheng; Joehanes, Roby; Justice, Anne E.; Katsuya, Tomohiro; Kaufman, Joel; Kerrison, Nicola D.; Khor, Chiea Chuen; Koh, Woon-Puay; Koistinen, Heikki A.; Komulainen, Pirjo; Kooperberg, Charles L.; Krieger, Jose E.; Kubo, Michiaki; Kuusisto, Johanna; Langefeld, Carl D.; Langenberg, Claudia; Launer, Lenore J.; Lehne, Benjamin; Lewis, Cora E.; Li, Yize; Lifelines Cohort Study; Lim, Sing Hui; Lin, Shiow; Liu, Ching-Ti; Liu, Jianjun; Liu, Jingmin; Liu, Kiang; Liu, Yeheng; Loh, Marie; Lohman, Kurt K.; Long, Jirong; Louie, Tin; Magi, Reedik; Mahajan, Anubha; Meitinger, Thomas; Metspalu, Andres; Milani, Lili; Momozawa, Yukihide; Morris, Andrew P.; Mosley, Thomas H. Jr.; Munson, Peter; Murray, Alison D.; Nalls, Mike A; Nasri, Ubaydah; Norris, Jill M.; North, Kari E.; Ogunniyi, Adesola; Padmanabhan, Sandosh; Palmas, Walter R.; Palmer, Nicholette D.; Pankow, James S.; Pedersen, Nancy L.; Peters, Annette; Peyser, Patricia A.; Polasek, Ozren; Raitakari, Olli T.; Renstrom, Frida; Rice, Treva K.; Ridker, Paul M.; Robino, Antonietta; Robinson, Jennifer G.; Rose, Lynda M.; Rudan, Igor; Sabanayagam, Charumathi; Salako, Babatunde L.; Sandow, Kevin; Schmidt, Carsten O.; Schreiner, Pamela J.; Scott, William R.; Seshadri, Sudha; Sever, Peter; Sitlani, Colleen M.; Smith, Jennifer A.; Snieder, Harold; Starr, John M.; Strauch, Konstantin; Tang, Hua; Taylor, Kent D.; Teo, Yik Ying; Tham, Yih Chung; Uitterlinden, Andre G.; Waldenberger, Melanie; Wang, Lihua; Wang, Ya X.; Wei, Wen Bin; Williams, Christine; Wilson, Gregory; Wojczynski, Mary K.; Yao, Jie; Yuan, Jian-Min; Zonderman, Alan B.; Becker, Diane M.; Boehnke, Michael; Bowden, Donald W.; Chambers, John C.; Chen, Yii-Der Ida; de Faire, Ulf; Deary, Ian J.; Esko, Tonu; Farrall, Martin; Forrester, Terrence; Franks, Paul W.; Freedman, Barry I.; Froguel, Philippe; Gasparini, Paolo; Gieger, Christian; Horta, Bernardo Lessa; Hung, Yi-Jen; Jonas, Jost B.; Kato, Norihiro; Kooner, Jaspal S.; Laakso, Markku; Lehtimaki, Terho; Liang, Kae-Woei; Magnusson, Patrik K. E.; Newman, Anne B.; Oldehinkel, Albertine J.; Pereira, Alexandre C.; Redline, Susan; Rettig, Rainer; Samani, Nilesh J.; Scott, James; Shu, Xiao-Ou; van der Harst, Pim; Wagenknecht, Lynne E.; Wareham, Nicholas J.; Watkins, Hugh; Weir, David R.; Wickremasinghe, Ananda R.; Wu, Tangchun; Zheng, Wei; Kamatani, Yoichiro; Laurie, Cathy C.; Bouchard, Claude; Cooper, Richard S.; Evans, Michele K.; Gudnason, Vilmundur; Kardia, Sharon L. R.; Kritchevsky, Stephen B.; Levy, Daniel; O'Connell, Jeff R.; Psaty, Bruce M.; van Dam, Rob M.; Sims, Mario; Arnett, Donna K.; Mook-Kanamori, Dennis O.; Kelly, Tanika N.; Fox, Ervin R.; Hayward, Caroline; Fornage, Myriam; Rotimi, Charles N.; Province, Michael A.; van Duijn, Cornelia M.; Tai, E. Shyong; Wong, Tien Yin; Loos, Ruth J. F.; Reiner, Alex P.; Rotter, Jerome I.; Zhu, Xiaofeng; Bierut, Laura J.; Gauderman, W. James; Caulfield, Mark J.; Elliott, Paul; Rice, Kenneth; Munroe, Patricia B.; Morrison, Alanna C.; Cupples, L. Adrienne; Rao, Dabeeru C.; & Chasman, Daniel I. (2018). A Large-Scale Multi-Ancestry Genome-Wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102(3), 375-400. PMCID: PMC5985266

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Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined approximately 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).




JOUR



Sung, Yun J.
Winkler, Thomas W.
de Las Fuentes, Lisa
Bentley, Amy R.
Brown, Michael R.
Kraja, Aldi T.
Schwander, Karen
Ntalla, Ioanna
Guo, Xiuqing
Franceschini, Nora
Lu, Yingchang
Cheng, Ching-Yu
Sim, Xueling
Vojinovic, Dina
Marten, Jonathan
Musani, Solomon K.
Li, Changwei
Feitosa, Mary F.
Kilpelainen, Tuomas O.
Richard, Melissa A.
Noordam, Raymond
Aslibekyan, Stella
Aschard, Hugues
Bartz, Traci M.
Dorajoo, Rajkumar
Liu, Yongmei
Manning, Alisa K.
Rankinen, Tuomo
Smith, Albert Vernon
Tajuddin, Salman M.
Tayo, Bamidele O.
Warren, Helen R.
Zhao, Wei
Zhou, Yanhua
Matoba, Nana
Sofer, Tamar
Alver, Maris
Amini, Marzyeh
Boissel, Mathilde
Chai, Jin Fang
Chen, Xu
Divers, Jasmin
Gandin, Ilaria
Gao, Chuan
Giulianini, Franco
Goel, Anuj
Harris, Sarah E.
Hartwig, Fernando Pires
Horimoto, Andrea R. V. R.
Hsu, Fang-Chi
Jackson, Anne U.
Kahonen, Mika
Kasturiratne, Anuradhani
Kuhnel, Brigitte
Leander, Karin
Lee, Wen-Jane
Lin, Keng-Hung
Luan, Jian 'an
McKenzie, Colin A.
Meian, He
Nelson, Christopher P.
Rauramaa, Rainer
Schupf, Nicole
Scott, Robert A.
Sheu, Wayne H. H.
Stancakova, Alena
Takeuchi, Fumihiko
van der Most, Peter J.
Varga, Tibor V.
Wang, Heming
Wang, Yajuan
Ware, Erin B.
Weiss, Stefan
Wen, Wanqing
Yanek, Lisa R.
Zhang, Weihua
Zhao, Jing Hua
Afaq, Saima
Alfred, Tamuno
Amin, Najaf
Arking, Dan
Aung, Tin
Barr, R. Graham
Bielak, Lawrence F.
Boerwinkle, Eric A.
Bottinger, Erwin P.
Braund, Peter S.
Brody, Jennifer A.
Broeckel, Ulrich
Cabrera, Claudia P.
Cade, Brian
Caizheng, Yu
Campbell, Archie
Canouil, Mickael
Chakravarti, Aravinda
CHARGE Neurology Working Group
Chauhan, Ganesh
Christensen, Kaare
Cocca, Massimiliano
COGENT-Kidney Consortium
Collins, Francis S.
Connell, John M.
de Mutsert, Renee
de Silva, H. Janaka
Debette, Stephanie
Dorr, Marcus
Duan, Qing
Eaton, Charles B.
Ehret, Georg
Evangelou, Evangelos
Faul, Jessica D.
Fisher, Virginia A.
Forouhi, Nita G.
Franco, Oscar H.
Friedlander, Yechiel
Gao, He
GIANT Consortium
Gigante, Bruna
Graff, Mariaelisa
Gu, C. Charles
Gu, Dongfeng
Gupta, Preeti
Hagenaars, Saskia P.
Harris, Tamara B.
He, Jiang
Heikkinen, Sami
Heng, Chew-Kiat
Hirata, Makoto
Hofman, Albert
Howard, Barbara V.
Hunt, Steven
Irvin, Marguerite Ryan
Jia, Yucheng
Joehanes, Roby
Justice, Anne E.
Katsuya, Tomohiro
Kaufman, Joel
Kerrison, Nicola D.
Khor, Chiea Chuen
Koh, Woon-Puay
Koistinen, Heikki A.
Komulainen, Pirjo
Kooperberg, Charles L.
Krieger, Jose E.
Kubo, Michiaki
Kuusisto, Johanna
Langefeld, Carl D.
Langenberg, Claudia
Launer, Lenore J.
Lehne, Benjamin
Lewis, Cora E.
Li, Yize
Lifelines Cohort Study
Lim, Sing Hui
Lin, Shiow
Liu, Ching-Ti
Liu, Jianjun
Liu, Jingmin
Liu, Kiang
Liu, Yeheng
Loh, Marie
Lohman, Kurt K.
Long, Jirong
Louie, Tin
Magi, Reedik
Mahajan, Anubha
Meitinger, Thomas
Metspalu, Andres
Milani, Lili
Momozawa, Yukihide
Morris, Andrew P.
Mosley, Thomas H. Jr.
Munson, Peter
Murray, Alison D.
Nalls, Mike A
Nasri, Ubaydah
Norris, Jill M.
North, Kari E.
Ogunniyi, Adesola
Padmanabhan, Sandosh
Palmas, Walter R.
Palmer, Nicholette D.
Pankow, James S.
Pedersen, Nancy L.
Peters, Annette
Peyser, Patricia A.
Polasek, Ozren
Raitakari, Olli T.
Renstrom, Frida
Rice, Treva K.
Ridker, Paul M.
Robino, Antonietta
Robinson, Jennifer G.
Rose, Lynda M.
Rudan, Igor
Sabanayagam, Charumathi
Salako, Babatunde L.
Sandow, Kevin
Schmidt, Carsten O.
Schreiner, Pamela J.
Scott, William R.
Seshadri, Sudha
Sever, Peter
Sitlani, Colleen M.
Smith, Jennifer A.
Snieder, Harold
Starr, John M.
Strauch, Konstantin
Tang, Hua
Taylor, Kent D.
Teo, Yik Ying
Tham, Yih Chung
Uitterlinden, Andre G.
Waldenberger, Melanie
Wang, Lihua
Wang, Ya X.
Wei, Wen Bin
Williams, Christine
Wilson, Gregory
Wojczynski, Mary K.
Yao, Jie
Yuan, Jian-Min
Zonderman, Alan B.
Becker, Diane M.
Boehnke, Michael
Bowden, Donald W.
Chambers, John C.
Chen, Yii-Der Ida
de Faire, Ulf
Deary, Ian J.
Esko, Tonu
Farrall, Martin
Forrester, Terrence
Franks, Paul W.
Freedman, Barry I.
Froguel, Philippe
Gasparini, Paolo
Gieger, Christian
Horta, Bernardo Lessa
Hung, Yi-Jen
Jonas, Jost B.
Kato, Norihiro
Kooner, Jaspal S.
Laakso, Markku
Lehtimaki, Terho
Liang, Kae-Woei
Magnusson, Patrik K. E.
Newman, Anne B.
Oldehinkel, Albertine J.
Pereira, Alexandre C.
Redline, Susan
Rettig, Rainer
Samani, Nilesh J.
Scott, James
Shu, Xiao-Ou
van der Harst, Pim
Wagenknecht, Lynne E.
Wareham, Nicholas J.
Watkins, Hugh
Weir, David R.
Wickremasinghe, Ananda R.
Wu, Tangchun
Zheng, Wei
Kamatani, Yoichiro
Laurie, Cathy C.
Bouchard, Claude
Cooper, Richard S.
Evans, Michele K.
Gudnason, Vilmundur
Kardia, Sharon L. R.
Kritchevsky, Stephen B.
Levy, Daniel
O'Connell, Jeff R.
Psaty, Bruce M.
van Dam, Rob M.
Sims, Mario
Arnett, Donna K.
Mook-Kanamori, Dennis O.
Kelly, Tanika N.
Fox, Ervin R.
Hayward, Caroline
Fornage, Myriam
Rotimi, Charles N.
Province, Michael A.
van Duijn, Cornelia M.
Tai, E. Shyong
Wong, Tien Yin
Loos, Ruth J. F.
Reiner, Alex P.
Rotter, Jerome I.
Zhu, Xiaofeng
Bierut, Laura J.
Gauderman, W. James
Caulfield, Mark J.
Elliott, Paul
Rice, Kenneth
Munroe, Patricia B.
Morrison, Alanna C.
Cupples, L. Adrienne
Rao, Dabeeru C.
Chasman, Daniel I.



2018


American Journal of Human Genetics

102

3

375-400








PMC5985266


10815

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