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Data resources & access

GENETIC FILES

DESCRIPTION

VARIABLES

OBSERVATIONS

ACCESS INFO

GENOME WIDE ASSOCIATION DATA

GWAS Data

At Wave IV, Add Health collected Oragene saliva samples from consenting participants (96% of n=15,701), and requested a second consent to archive their samples for future genomic studies. Approximately 80% consented to archive and were thus eligible for genome-wide genotyping. Genotyping was completed over three years funded by R01 HD073342 (PI Harris) and R01 HD060726 (PIs Harris, Boardman, and McQueen). Add Health utilized two Illumina platforms for genotyping: the Illumina Human Omni1-Quad BeadChip for the majority of samples and the Illumina Human Omni-2.5 Quad BeadChip for the remainder. The two platforms utilized tag SNP technology to identify and include over 1.1 million and 2.5 million genetic markers respectively from Omni1 and Omni2.5 derived from the International HapMap Project and the most informative markers from the 1000 Genomes Project (1KGP). The genetic markers include known disease-associated SNPs from multiple sources, ancestry-informative markers, sex chromosomes, and ABO blood typing markers. The platforms also included probes for the detection of copy number variation (CNV) covering all common CNV regions and more than 5,000 rare CNV regions. After quality control procedures (described below), genotype data were available for 9,974 individuals: n=7,917 from the Illumina HumanOmni1-Quad chip and for 2,057 individuals from the Illumina HumanOmni2.5-Quad chip. After filtering, the Add Health genotype GWAS data contained n=609,130 single-nucleotide polymorphisms (SNPs) common to both chips to enable joint imputation to the entire Add Health population.

Over 1.1 million and 2.5 million genetic markers respectively from Omni1 and Omni2.5 derived from the International HapMap Project and the most informative markers from the 1000 Genomes Project (1KGP) 9,974  dbGaP Data Use Agreement

POLYGENIC SCORES

Wave IV Genetic Risk Score* - BMI

This file contains the BMI genetic risk score* for Add Health twin and full sibling respondents who provided saliva samples at Wave IV.

*Polygenic Score

2 1,886 Add Health Restricted-Use Data Contract

 Wave IV Genetic Risk Score* - Education

An education genetic risk score* (GRS_EDU) is available for Add Health twin and full sibling respondents who provided saliva samples at Wave IV. This variable is the weighted sum of risk alleles identified in the Rietveld et al. (2013) genome-wide association study.

*Polygenic Score

1,886

 

Add Health Restricted-Use Data Contract

Wave IV Polygenic Scores

Thirty constructed polygenic scores (PGS) are available for Add Health respondents who provided archival saliva samples for genetic testing at Wave IV. Scores are available for coronary artery disease, myocardial infarction, plasma cortisol, LDL cholesterol, HDL cholesterol, total cholesterol, triglycerides, type II diabetes (2 measures), BMI, waist circumference, waist-to-hip ratio, height, age at menarche, age at menopause, number of children, age at first birth, ever/current smoker, number of cigarettes per day, extraversion, attention deficit disorder (2 measures), bipolar disorder, major depressive disorder (2 measures), schizophrenia, mental health cross disorder, Alzheimer’s disease, and educational attainment (2 measures).

 53

9,129

Add Health Restricted-Use Data Contract

 

Wave IV Polygenic Scores - SSGAC

 

Polygenic scores (PGS) constructed by the Social Science Genetic Association Consortium (SSGAC) are available for Add Health respondents who provided archival saliva samples for genetic testing at Wave IV. This data file contains educational attainment, cognitive performance, depression, neuroticism, and subjective well-being scores based on standard GWAS summary statistics and multilevel analysis (2 scores for each construct).  Additional multivariate analysis scores for highest level math taken and math ability are also included.

 

23

5,690

Add Health Restricted-Use Data Contract 

CANDIDATE GENES

 

 

 

Wave III DNA Data

Twin and full siblings interviewed at Wave III were asked to provide saliva samples for DNA analysis. This file contains the genotype values for DAT1 (dopamine transporter), DRD4 (dopamine receptor), and SLC6A4 (serotonin transporter), MAOA_V (monoamine oxidase A-uVNTR), DRD2 (dopamine D2 receptor), and CYP2A6 (cytochrome P450 2A6) from these samples. Also included are values for the following SNPs: rs2304297, rs892413, rs4950, rs13280604.

24

2,574

 Add Health Restricted-Use Data Contract

Wave IV DNA Data

Contains genotyping results for all Wave IV respondents who agreed to provide a saliva sample for DNA testing. This dataset has values for DAT1 (dopamine transporter), DRD4 (dopamine receptor), MAOA (monoamine oxidase A-uVNTR), 5HTTLPR (serotonin transporter), HTTLPR La-Lg-S, triallelic activity bins for the serotonin transporter 5HTTLPR adjusted for rs25531, DRD2, s000005, s000006, DRD5, and MAOCA1

30

15,701

Add Health Restricted-Use Data Contract