Genetic Risk, Body Mass Index, and Weight Control Behaviors: Unlocking the Triad

Nagata, Jason M.; Braudt, David B.; Domingue, Benjamin W.; Bibbins-Domingo, Kirsten; Garber, Andrea K.; Griffiths, Scott; & Murray, Stuart B. (2019). Genetic Risk, Body Mass Index, and Weight Control Behaviors: Unlocking the Triad. International Journal of Eating Disorders, 52(7), 825-33.

Nagata, Jason M.; Braudt, David B.; Domingue, Benjamin W.; Bibbins-Domingo, Kirsten; Garber, Andrea K.; Griffiths, Scott; & Murray, Stuart B. (2019). Genetic Risk, Body Mass Index, and Weight Control Behaviors: Unlocking the Triad. International Journal of Eating Disorders, 52(7), 825-33.

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BACKGROUND: The relationship between genetic risk for body mass index (BMI) and weight control behaviors remains unknown. The objectives of this study were to determine the association between genetic risk for BMI and weight control behaviors in young adults, and to examine actual measured BMI as a potential mediator variable. METHOD: We analyzed data from three data collection waves of the National Longitudinal Study of Adolescent to Adult Health. The BMI polygenic score (PGS) was based on published genome-wide association studies for BMI. BMI was collected at 11-18 years and 18-26 years. Weight control behaviors included self-reported: (a) weight loss behaviors (dieting, vomiting, fasting/skipping meals, diet pills, laxatives, or diuretic use to lose weight) and (b) weight gain behaviors (eating more or different foods than normal, taking supplements to gain weight). RESULTS: Among 4,397 participants, the BMI PGS was associated with higher odds of weight loss behaviors in females (OR 1.24, 95% CI 1.14-1.35) and males (OR 1.43, 95% CI 1.26-1.62), and this association was mediated by BMI (indirect effect 0.04, 95% CI 0.03-0.05 in females and 0.03, 95% CI 0.03-0.04 in males). The BMI PGS was associated with lower odds of weight gain behaviors in females and males, which was also mediated by actual BMI. CONCLUSIONS: The BMI PGS was associated with weight loss behaviors in both males and females, and this association was mediated by actual measured BMI. Clinical interventions to prevent high BMI, particularly for individuals with genetic risk, may also prevent subsequent development of potentially unhealthy weight loss behaviors.




JOUR



Nagata, Jason M.
Braudt, David B.
Domingue, Benjamin W.
Bibbins-Domingo, Kirsten
Garber, Andrea K.
Griffiths, Scott
Murray, Stuart B.



2019

P2C-No. NIH-Yes. "Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Numbers: 5R01HD082166‐02, K12HD00085033; National Health and Medical Research Council, Grant/Award Number: 1121538; National Institute of Mental Health, Grant/Award Number: K23 MH115184."

International Journal of Eating Disorders

52

7

825-33










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