Assessment of Placental Metal Levels in a South African Cohort

Meyrueix, Laetitia; Adair, Linda S.; Norris, Shane A.; & Ideraabdullah, Folami. (2019). Assessment of Placental Metal Levels in a South African Cohort. Environmental Monitoring and Assessment, 191(8), 500.

Meyrueix, Laetitia; Adair, Linda S.; Norris, Shane A.; & Ideraabdullah, Folami. (2019). Assessment of Placental Metal Levels in a South African Cohort. Environmental Monitoring and Assessment, 191(8), 500.

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The placenta plays an important role in mediating the effect of maternal metal exposure on fetal development, acting as both barrier and transporter. Term-placenta metal levels serve as an informative snapshot of maternal/fetal exposure during pregnancy and could be used to predict offspring short- and long-term health outcomes. Here, we measured term-placenta metal levels of 11 metals in 42 placentas from the Soweto First 1000 days cohort (S1000, Soweto-Johannesburg, SA). We compared these placental metal concentrations with previously reported global cohort measurements to determine whether this cohort is at increased risk of exposure. Placental metals were tested for correlations to understand potential interactions between metals. Since these samples are from a birth cohort study, we also performed exploratory analyses to determine whether metal levels were associated with placenta and birth outcomes. Most S1000 placental metal levels were similar to other cohorts; however, cadmium (Cd) levels up to 50-fold lower, and essential elements nickel (Ni) and chromium (Cr) level up to 6- and 16-fold lower, respectively. Cd, Se, and Ni were associated with placenta and birth outcomes. Studies are ongoing to examine underlying mechanisms and how these developmental differences affect long-term health.




JOUR



Meyrueix, Laetitia
Adair, Linda S.
Norris, Shane A.
Ideraabdullah, Folami



2019

P2C-No. T32-Yes. "National Institute of Environmental Health Sciences (NIEHS)-P30ES010126 to the UNC Biomarker and Mass Spectrometry Core for placental metal measurements; NIEHS Transition to Independent Environmental Health Research Career Development Award [KES023849A] to FI for study design, data analyses, data interpretation, and manuscript writing; the UK Medical Research Council (MRC) DFID African Research Leader Scheme Award to SN for sample and data collection, data interpretation, and manuscript writing; and the T32 predoctoral fellowship from the National Heart, Lung, and Blood Institute (NHLBI) funded by Global Cardiometabolic Disease Training Grant [5T32HL129969] to LM for data analyses, data interpretation, and manuscript writing. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."

Environmental Monitoring and Assessment

191

8

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