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The Genetic Underpinnings of Variation in Ages at Menarche and Natural Menopause among Women from the Multi-Ethnic Population Architecture Using Genomics and Epidemiology (PAGE) Study: A Trans-Ethnic Meta-Analysis

Citation

Fernandez-Rhodes, Lindsay; Malinowski, Jennifer R.; Wang, Yujie; Tao, Ran; Pankratz, Nathan; Jeff, Janina M.; Yoneyama, Sachiko; Carty, Cara L.; Setiawan, V. Wendy; & Le Marchand, Loic, et al. (2018). The Genetic Underpinnings of Variation in Ages at Menarche and Natural Menopause among Women from the Multi-Ethnic Population Architecture Using Genomics and Epidemiology (PAGE) Study: A Trans-Ethnic Meta-Analysis. PLOS ONE, 13(7), e0200486. PMCID: PMC6059436

Abstract

Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natural menopause (ANM) in diverse populations remains unclear. We investigated 32 AAM and 14 ANM previously-identified loci and sought to identify novel loci in a trans-ethnic array-wide study of 196,483 SNPs on the MetaboChip (Illumina, Inc.). A total of 45,364 women of diverse ancestries (African, Hispanic/Latina, Asian American and American Indian/Alaskan Native) in the Population Architecture using Genomics and Epidemiology (PAGE) Study were included in cross-sectional analyses of AAM and ANM. Within each study we conducted a linear regression of SNP associations with self-reported or medical record-derived AAM or ANM (in years), adjusting for birth year, population stratification, and center/region, as appropriate, and meta-analyzed results across studies using multiple meta-analytic techniques. For both AAM and ANM, we observed more directionally consistent associations with the previously reported risk alleles than expected by chance (p-values binomial

URL

http://dx.doi.org/10.1371/journal.pone.0200486

Reference Type

Journal Article

Year Published

2018

Journal Title

PLOS ONE

Author(s)

Fernandez-Rhodes, Lindsay
Malinowski, Jennifer R.
Wang, Yujie
Tao, Ran
Pankratz, Nathan
Jeff, Janina M.
Yoneyama, Sachiko
Carty, Cara L.
Setiawan, V. Wendy
Le Marchand, Loic
Haiman, Christopher A.
Corbett, Steven
Demerath, Ellen W.
Heiss, Gerardo M.
Gross, Myron D.
Buzkova, Petra
Crawford, Dana C.
Hunt, Steven C.
Rao, Dabeeru C.
Schwander, Karen
Chakravarti, Aravinda
Gottesman, Omri
Abul-Husn, Noura S.
Bottinger, Erwin P.
Loos, Ruth J. F.
Raffel, Leslie J.
Yao, Jie
Guo, Xiuqing
Bielinski, Suzette J.
Rotter, Jerome I.
Vaidya, Dhananjay
Chen, Yii-Der Ida
Castaneda, Sheila F.
Daviglus, Martha L.
Kaplan, Robert C.
Talavera, Gregory A.
Ryckman, Kelli K.
Peters, Ulrike
Ambite, Jose Luis
Buyske, Steven G.
Hindorff, Lucia A.
Kooperberg, Charles L.
Matise, Tara C.
Franceschini, Nora
North, Kari E.

PMCID

PMC6059436