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Association between Early Parental Deprivation and Cellular Immune Function among Adults in Rural Fujian, China

Citation

Yazawa, Aki; Inoue, Yosuke; Cai, Guoxi; Tu, Raoping; Huang, Meng; He, Fei; Chen, Jie; Yamamoto, Taro; & Watanabe, Chiho (2019). Association between Early Parental Deprivation and Cellular Immune Function among Adults in Rural Fujian, China. Developmental Psychobiology, 61(7), 1094-1099. PMCID: PMCID6989117

Abstract

This study investigated the role of childhood parental deprivation in the association between quality of life (QOL) and the Epstein-Barr virus (EBV) antibody titer, a marker of cellular immune functioning, using data from 734 adults living in seven communities in rural Fujian, China. Parental deprivation was defined if either of their parents had died, divorced, or left them for migratory work for more than 1 year before they turned (a) 16 years of age (childhood and adolescence), or (b) 3 years of age (early childhood). A mixed-effects regression analysis with a random effects model revealed that parental deprivation during early childhood was positively associated with the EBV antibody titer (coefficient = 0.33, p = 0.007), whereas parental deprivation during the first 16 years was not. Further analysis incorporating an interaction term between QOL and parental deprivation revealed a significant interaction between QOL and parental deprivation during early childhood; a significant association between QOL and the EBV antibody titer was found only among those who reported parental deprivation during early childhood. This study suggests that parental deprivation during the period of immune system development may be linked with physiological responses to stressors later in life.

URL

http://dx.doi.org/10.1002/dev.21886

Reference Type

Journal Article

Year Published

2019

Journal Title

Developmental Psychobiology

Author(s)

Yazawa, Aki
Inoue, Yosuke
Cai, Guoxi
Tu, Raoping
Huang, Meng
He, Fei
Chen, Jie
Yamamoto, Taro
Watanabe, Chiho

PMCID

PMCID6989117