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Methylome-Wide Association Study of Central Adiposity Implicates Genes Involved in Immune and Endocrine Systems

Citation

Justice, Anne E.; Chittoor, Geetha; Gondalia, Rahul; Melton, Phillip E.; Lim, Elise; Grove, Megan L.; Whitsel, Eric A.; Liu, Ching-Ti; Cupples, L. Adrienne; & Fernandez-Rhodes, Lindsay, et al. (2020). Methylome-Wide Association Study of Central Adiposity Implicates Genes Involved in Immune and Endocrine Systems. Epigenomics, 12(17), 1483-1499.

Abstract

Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.
Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).
Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

URL

http://dx.doi.org/10.2217/epi-2019-0276

Reference Type

Journal Article

Article Type

Regular

Year Published

2020

Journal Title

Epigenomics

Author(s)

Justice, Anne E.
Chittoor, Geetha
Gondalia, Rahul
Melton, Phillip E.
Lim, Elise
Grove, Megan L.
Whitsel, Eric A.
Liu, Ching-Ti
Cupples, L. Adrienne
Fernandez-Rhodes, Lindsay
Guan, Weihua
Bressler, Jan
Fornage, Myriam
Boerwinkle, Eric
Li, Yun
Demerath, Ellen W.
Heard-Costa, Nancy L.
Levy, Daniel
Stewart, James D.
Baccarelli, Andrea A.
Hou, Lifang
Conneely, Karen N.
Mori, Trevor A.
Beilin, Lawrence J.
Huang, Rae-Chi
Gordon-Larsen, Penny
Howard, Annie Green
North, Kari E.

Data Set/Study

Women's Health Initiative and Framingham Heart Study

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

African-American
European American