Menu Close

Immune Response to Cytomegalovirus and Cognition in the Health and Retirement Study

Citation

Stebbins, Rebecca C.; Noppert, Grace A.; Yang, Yang Claire; Dowd, Jennifer B.; Simanek, Amanda M.; & Aiello, Allison E. (Online ahead of print). Immune Response to Cytomegalovirus and Cognition in the Health and Retirement Study. American Journal of Epidemiology. PMCID: PMC Journal - In Process

Abstract

Chronic infections and the subsequent immune response have recently been shown to be risk factors for cognitive decline and Alzheimer's Disease and related disorders (ADRD). While some studies have shown an association between cytomegalovirus (CMV), a chronic and highly prevalent infection, and cognition and/or ADRD, these are limited by non-representative and small samples. Using data from 5,617 adults aged 65 years and older from the 2016 Health and Retirement Study, we investigated the cross-sectional association between both CMV serostatus and IgG antibody response and cognitive function using linear regression models adjusted for age, sex, race/ethnicity, and educational attainment. We further investigated potential effect measure modification by educational attainment. Overall, both CMV seropositivity and higher IgG were associated with lower cognitive function, though the relationship was not statistically significant in adjusted models. Among those with less than a high school diploma, CMV seropositivity and being in the first tertile of IgG response relative to seronegatives were associated with lower TICS score (-0.56 (95%CI: -1.63, 0.52) and -0.89 (95%CI: -2.07, 0.29), respectively), and the relationship was attenuated among those with higher education. Our results suggest that CMV may be a risk factor for cognitive impairment, particularly among those with low educational resources.

URL

http://dx.doi.org/10.1093/aje/kwaa238

Notes

biolist Noppert // Noppert left 2020 // Stebbins left 2017

Reference Type

Journal Article

Journal Title

American Journal of Epidemiology

Author(s)

Stebbins, Rebecca C.
Noppert, Grace A.
Yang, Yang Claire
Dowd, Jennifer B.
Simanek, Amanda M.
Aiello, Allison E.

Year Published

Online ahead of print

PMCID

PMC Journal - In Process

Reference ID

13265