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Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children

Citation

Barragán-Vázquez, Sofia; Ariza, Ana Carolina; Ramírez Silva, Ivonne; Pedraza, Lilia S.; Rivera Dommarco, Juan A.; Ortiz-Panozo, Eduardo; Zambrano, Elena; Reyes Castro, Luis A.; Shivappa, Nitin; & Hébert, James R., et al. (2020). Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children. Nutrients, 12(12), e3658. PMCID: PMC7760203

Abstract

There is limited evidence about the inflammatory potential of diet in children. The aim of this study was to evaluate the association between the Children's Dietary Inflammatory Index (C-DII) from 5 to 11 years with adiposity and inflammatory biomarkers in Mexican children. We analyzed 726 children from a birth cohort study with complete dietary information and measurements to evaluate adiposity at 5, 7 and 11 y and 286 children with IL-6, hsCRP, leptin and adiponectin information at 11 y. C-DII trajectories were estimated using latent class linear mixed models. We used linear mixed models for adiposity and logistic and multinomial regression for biomarkers. In girls, each one-point increase in C-DII score was associated with greater adiposity (abdominal-circumference 0.41%, p = 0.03; skinfold-sum 1.76%, p = 0.01; and BMI Z-score 0.05, p = 0.01). At 11 y the C-DII was associated with greater leptin (34% ≥ 13.0 ng/mL, p = 0.03) and hsCRP concentrations (29% ≥ 3.00 mg/L, p = 0.06) and lower adiponectin/leptin ratio (75% < 2.45, p = 0.02). C-DII trajectory 3 in boys was associated with a 75.2% (p < 0.01) increase in leptin concentrations and a 37.9% decrease (p = 0.02) in the adiponectin/leptin ratio. This study suggests that the inflammatory potential of diet may influence adiposity in girls and the homeostasis of adipose tissue and chronic subclinical inflammation in 11-year-old children.

URL

http://dx.doi.org/10.3390/nu12123658

Reference Type

Journal Article

Article Type

Regular

Year Published

2020

Journal Title

Nutrients

Author(s)

Barragán-Vázquez, Sofia
Ariza, Ana Carolina
Ramírez Silva, Ivonne
Pedraza, Lilia S.
Rivera Dommarco, Juan A.
Ortiz-Panozo, Eduardo
Zambrano, Elena
Reyes Castro, Luis A.
Shivappa, Nitin
Hébert, James R.
Martorell, Reynaldo
Stein, Aryeh D.
Barraza-Villarreal, Albino
Romieu, Isabelle
Avila-Jiménez, Laura
Ramakrishnan, Usha

PMCID

PMC7760203

Data Set/Study

Prenatal Omega-3 fatty acid supplementation and child growth and development study (POSGRAD)

Continent/Country

Mexico