Menu Close

SARS-CoV-2 Seropositivity after Infection and Antibody Response to mRNA-Based Vaccination

Citation

Ciccone, Emily J.; Zhu, Deanna R.; Ajeen, Rawan; Lodge, Evans K.; Shook-Sa, Bonnie E.; Boyce, Ross M.; & Aiello, Allison E. (Preprint). SARS-CoV-2 Seropositivity after Infection and Antibody Response to mRNA-Based Vaccination. medRxiv. PMCID: PMC7899463

Abstract

The effect of SARS-CoV-2 infection on response to mRNA-based SARS-CoV-2 vaccines is not well-described. We assessed longitudinal SARS-CoV-2-specific antibody responses pre- and post-vaccination among individuals with and without prior infection. The antibody response to the first vaccine dose was almost two-fold higher in individuals who were seropositive before vaccination compared to those who were seronegative, suggesting that prior infection primes the immune response to the first dose of mRNA-based vaccine.

URL

http://dx.doi.org/10.1101/2021.02.09.21251319

Reference Type

Journal Article

Year Published

Preprint

Journal Title

medRxiv

Author(s)

Ciccone, Emily J.
Zhu, Deanna R.
Ajeen, Rawan
Lodge, Evans K.
Shook-Sa, Bonnie E.
Boyce, Ross M.
Aiello, Allison E.

Article Type

Regular

PMCID

PMC7899463

Continent/Country

United States of America

ORCiD

Aiello - 0000-0001-7029-2537
Boyce, R - 0000-0002-9489-6324
Lodge - 0000-0002-2222-5441