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Recent SARS-CoV-2 Seroconversion in a National, Community-Based Prospective Cohort of U.S. Adults

Citation

Nash, Denis; Rane, Madhura; Chang, Mindy; Kulkarni, Sarah Gorrell; Zimba, Rebecca; You, William; Berry, Amanda; Mirzayi, Chloe; Kochhar, Shivani; & Maroko, Andrew, et al. (Preprint). Recent SARS-CoV-2 Seroconversion in a National, Community-Based Prospective Cohort of U.S. Adults. medRxiv. PMCID: PMC7899475

Abstract

Epidemiologic risk factors for incident SARS-CoV-2 infection are best characterized via prospective cohort studies, complementing case-based surveillance and cross-sectional seroprevalence studies. In March 2020, we launched the CHASING COVID Cohort Study, a national, community-based prospective cohort study of 6,745 U.S. adults who underwent at-home specimen collection for repeat serologic testing for SARS-CoV-2 antibodies. We identify and quantify several policy-sensitive risk factors for recent SARS-CoV-2 seroconversion, highlight persistent racial/ethnic disparities in incidence, document continued elevated risk among essential workers, and call attention to major gaps in the coverage of public health interventions aimed at testing, isolation, and contact tracing. We conclude that modifiable risk factors and poor reach of public health strategies drive SARS-CoV-2 transmission and inequities across the U.S.

URL

http://dx.doi.org/10.1101/2021.02.12.21251659

Reference Type

Journal Article

Year Published

Preprint

Journal Title

medRxiv

Author(s)

Nash, Denis
Rane, Madhura
Chang, Mindy
Kulkarni, Sarah Gorrell
Zimba, Rebecca
You, William
Berry, Amanda
Mirzayi, Chloe
Kochhar, Shivani
Maroko, Andrew
Robertson, McKaylee
Westmoreland, Drew
Parcesepe, Angela M.
Waldron, Levi
Grov, Christian

Article Type

Regular

PMCID

PMC7899475

Data Set/Study

CHASING COVID Cohort Study

Continent/Country

United States of America

State

Nonspecific

ORCiD

Parcesepe - 0000-0002-4321-125x