CitationDuchowny, Kate A. & Noppert, Grace A. (Online ahead of print). The Association Between Cytomegalovirus and Disability by Race/Ethnicity and Gender: Results from the Health and Retirement Study. American Journal of Epidemiology. PMCID: PMC Journal - In Process
AbstractRecent studies have documented a decline in the overall prevalence of disability in the United States, however racial/ethnic and gender disparities continue to persist. Cytomegalovirus (CMV), a socially patterned exposure, may be a key mechanism in understanding these previously documented disparities. Using data from the nationally-representative 2016 Health and Retirement Study, we employed Poisson log-binomial models to estimate the prevalence of disability comparing CMV seropositive versus seronegative adults and investigated effect modification by race/ethnicity and gender. Among the 9,029 participants (55% women, mean age: 67.4), 63% were CMV seropositive and 15% were disabled. CMV seropositivity was highest among non-Hispanic Black (88%) and Hispanic adults (92%) compared to non-Hispanic White adults (57%). We found evidence for effect modification of the CMV-disability by gender but not race/ethnicity. While the confidence intervals in the fully-adjusted models included the null value, compared to seronegative women, our results suggest a greater prevalence of disability among CMV seropositive women (PR= 1.16, 95% CI= 0.97, 1.39) but not among men (PR= 0.85, 95% CI= 0.69, 1.06). Results provide initial support that CMV may be an important determinant of gender disparities in disability.
Reference TypeJournal Article
Year PublishedOnline ahead of print
Journal TitleAmerican Journal of Epidemiology
Author(s)Duchowny, Kate A.
Noppert, Grace A.