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Molecular Epidemiology of Type 1 Diabetes in China

Strotmeyer, Elsa Sophia Siulc. (2000). Molecular Epidemiology of Type 1 Diabetes in China. Master's thesis / Doctoral dissertation, University of Pittsburgh.

Strotmeyer, Elsa Sophia Siulc. (2000). Molecular Epidemiology of Type 1 Diabetes in China. Master's thesis / Doctoral dissertation, University of Pittsburgh.

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Type 1 diabetes has a very low incidence in China, although the reasons for this have not been well studied. In order to consider some environmental factors associated with type 1 diabetes, a subset of registry cases (N = 292) from China and sex, age, ethnic, and geographically matched controls (N = 496) without diabetes were studied. Local centers throughout mainland China collected questionnaire data regarding medical history, demographics, and environmental exposure, and biologic samples for genetic, immunologic, and C-peptide measures from cases and controls. The cases recruited for study were shown to be representative of the entire Chinese registry population. Type 1 diabetes cases were 47% male, had a mean age of onset of 9.6 ± 3.5 years, and had a mean age of clinic visit of 14.2 ± 4.5 years. Ethnic origin of cases was 97% Han, 1.4% Mongol, 1.0% Hui, and 0.7% Man. Based on fasting C-peptide tests and evaluation of immunologic markers (GAD and IA-2) of type 1 diabetes, our sample of registry cases were determined to have autoimmune type 1 diabetes. Socioeconomic group and birth cohort were strongly related to food consumption in infancy for both cases and controls. SES was lower in cases compared to controls (38% low, 54% medium, 8% high vs. 26% low, 66% medium, 8% high; p < 0.01). In multivariate logistic regression analyses which controlled for SES, birth year, and breastfeeding status, soy formula consumption from 6-12 months of age was a risk factor for type 1 diabetes (OR = 1.44; 95%CI: 1.01-2.05; p < 0.05) and steamed bread consumption at 4-6 (OR = 0.65; 95%CI: 0.45-0.94; p < 0.05) and 6-12 months of age (OR = 0.54; 95%CI: 0.38-0.77; p < 0.001), fish consumption at 6-12 months of age (OR = 0.63; 95%CI: 0.42-0.95; p < 0.05), and noodle consumption at 6-12 months of age (OR = 0.60; 95%CI: 0.39-0.91; p < 0.05) were protective for type 1 diabetes. More cases were introduced to solid food by 3 months of age than controls (21% vs. 14%; p < 0.05). Infant diet may play a more important role etiology than previously considered. Differences in genetics and environmental risk factors, such as nutrition, may explain the lower incidence found in China compared with other populations.




THES



Strotmeyer, Elsa Sophia Siulc


Dorman, Janice S.

2000



9998593


300-300 p.




University of Pittsburgh

Pittsburgh

9780493068732; 0493068732




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