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Clinical Usefulness of Lipid Ratios, Visceral Adiposity Indicators, and the Triglycerides and Glucose Index As Risk Markers of Insulin Resistance

Du, Tingting; Yuan, Gang; Zhang, Muxun; Zhou, Xinrong; Sun, Xing-xing; & Yu, Xuefeng. (2014). Clinical Usefulness of Lipid Ratios, Visceral Adiposity Indicators, and the Triglycerides and Glucose Index As Risk Markers of Insulin Resistance. Cardiovascular diabetology, 13(1), 146. PMCID: PMC4209231

Du, Tingting; Yuan, Gang; Zhang, Muxun; Zhou, Xinrong; Sun, Xing-xing; & Yu, Xuefeng. (2014). Clinical Usefulness of Lipid Ratios, Visceral Adiposity Indicators, and the Triglycerides and Glucose Index As Risk Markers of Insulin Resistance. Cardiovascular diabetology, 13(1), 146. PMCID: PMC4209231

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BackgroundTo directly compare traditional lipid ratios (total cholesterol [TC]/high density lipoprotein cholesterol [HDL-C], non-HDL-C/HDL-C, low density lipoprotein cholesterol [LDL-C]/HDL-C, and triglycerides [TG]/HDL-C), apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio, visceral adiposity index (VAI), lipid accumulation product (LAP), and the product of TG and fasting glucose (TyG) for strength and independence as risk factors for insulin resistance (IR).MethodsWe conducted a cross-sectional analysis of 7629 Chinese adults using data from the China Health and Nutrition Survey 2009.ResultsFor all lipid ratios (traditional lipid ratios and apoB/apoA-I), among both sexes, TG/HDL-C explained the most additional percentage of variation in HOMA-IR (2.9% in men, and 2.3% in women); for all variables of interest, the variability in HOMA-IR explained by VAI and TG/HDL-C were comparable; TyG had the most significant association with HOMA-IR, which explained 9.1% for men and 7.8% for women of the variability in HOMA-IR. Logistic regression analysis showed the similar patterns. Receiver operating characteristic (ROC) curve analysis showed that, among both sexes, TG/HDL-C was a better discriminator of IR than apoB/apoA-I; the area under the ROC curve (AUC) for VAI (0.695 in men and 0.682 in women) was greater than that for TG/HDL-C (AUC 0.665 in men and 0.664 in women); TyG presented the greatest value of AUC (0.709 in men and 0.711 in women).ConclusionThe apoB/apoA-I performs no better than any of the traditional lipid ratios in correlating with IR. The TG/HDL-C, VAI and TyG are better markers for early identification of IR individuals.




JOUR



Du, Tingting
Yuan, Gang
Zhang, Muxun
Zhou, Xinrong
Sun, Xing-xing
Yu, Xuefeng



2014


Cardiovascular diabetology

13

1

146


2014/10/20




1475-2840 (Electronic) 1475-2840 (Linking)

10.1186/preaccept-1207347889137599

PMC4209231


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