Long-Term Low Intake of Dietary Calcium and Fracture Risk in Older Adults with Plant-Based Diet: A Longitudinal Study from the China Health and Nutrition Survey
2460.ris
—
Octet Stream,
2 kB (2,356 bytes)
The aim of this longitudinalstudy was to investigate long-term associations between low dietary calcium intake and fracturerisk in older adults with plant-based diet.Dataof self-reported first fracture events of any typefrom 6210 Chinese men and women, aged 50 years or over and free from fracture at baseline, in a subcohort based on the China Health and Nutrition Survey, were analyzed. Diet was repeatedly assessed by a combination of three consecutive 24-hour individual dietary recalls, and a weighing and measuring household food inventory in each round. The older men and women habitually ingested mean (SD) of 415(147)mg/d and 373(140) mg/d of calcium from plant-based diet, respectively. During a median follow-up of 7.0 years, 127 men (4.34%) and 232 women (7.06%)experienced first fracture events.The crude rates were 4.88, 2.55, and 6.83 per 1000 person years at risk for men,and 6.72, 7.10, and 11.0 per 1000 person years at risk for women in the lowest, third, and highest quintile of dietary calcium intake. In non-linear regressions, an increased risk of fracture was associated with dietary calcium intake more than 778 mg/d (multivariable adjusted hazard ratio [HR] 2.10, 95% confidence interval [CI] 1.00-4.41) or lower than 275 mg/d(1.74, 95% CI 1.00-3.01)for men,and more than 651 mg/d for women (1.54, 95% CI 1.00-2.38);And a non-significant trend of increase in fracture risk was found below 248 mg/d (1.00, 95% CI 0.67-1.50) in womenusing restricted cubicspline Cox regression.A relatively low fracture risk is observed in men with dietary calcium intakes of 275-780mg/d and in women with intakes of 250-650mg/d, and higher intakes may have no further benefit for fracture prevention. The patterns of dietary calcium with fracture risk are U-shaped in men and possibly in women. This article is protected by copyright. All rights reserved
JOUR
Fang, Aiping
Li, Keji
Guo, Meihan
He, Jingjing
Li, He
Shen, Xin
Song, Jie
2016
Journal of Bone and Mineral Research
31
11
2016-23
1523-4681
10.1002/jbmr.2874
2460