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Introduction

 

SNPs: Single Nucleotide Polymorphisms
U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov.
Image Use and Credits Almost all the images on these pages are original graphics created by the U.S. Department of Energy Genome Program's Genome Management Information System (GMIS). You will recognize GMIS images by their credit line. Permission to use these graphics is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. All other images were provided by third parties and not created by the U.S. Department of Energy. You must contact the person listed in the credit line before using those images.

 

  Incorporating Biomarkers

 

 

Micrograph showing a cross-section of coronary artery narrowed by fibrolipid plaque.
http://www.genome.gov/pressDisplay.cfm?photoID=20026
This image is freely available and may be used without special permission.
Courtesy: National Human Genome Research Institute


Diagnosing Sjogren's Syndrome by measuring salivary gland flow rate
http://www.nidcr.nih.gov/Research/NIDCRLaboratories/MolecularPhysiology/SjogrensSyndrom
e/SjogrensSyndromeClinic.htm#what


Before Collection

Chromosome pairs
http://ghr.nlm.nih.gov/handbook/basics/howmanychromosomes

Escherichia coli (E. coli)
http://publications.nigms.nih.gov/thenewgenetics/livinglab.html


Study Design Issues

Cracked paint

Blood serum aliquots being removed from production stock inventory.
Public Health Image Library -- CDC

http://phil.cdc.gov/phil_images/20030416/7/PHIL_3581_lores.jpg

Measurement and Size

Microplate, a lab equipment item
http://publications.nigms.nih.gov/thenewgenetics/chapter5.html#c6

Ferritin, a protein made up of 24 identical subunits, is involved in iron storage.
http://ghr.nlm.nih.gov/handbook/illustrations/ferritin.jpg

 

 

Measures Used
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xstudy_design_issues/measures_used

Dermal absorption rates: Skin contact with pesticides
http://www.ars.usda.gov/Services/docs.htm?docid=14624

Dietary source of cholesterol and related lipids
http://www.cdc.gov/NCEH/DLS/cholesterol.htm

Recording blood pressure
http://diabetes.niddk.nih.gov/dm/pubs/gestational/#9

Red blood cells infected by Plasmodium falciparum malaria
http://www.cdc.gov/malaria/features/malaria_lab_diagnosis.htm

Clostridium tetani bacteria, responsible for causing tetanus in humans
http://phil.cdc.gov/PHIL_Images/20041014/b9e12f3f8918406b960fa8f84cc4c533/6372_lores.jpg

Lab Selection
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xlab_selection

 

 

Sensitivity:  Sensitivity, specificity, and predictive values of serological tests for antibody to A
antigen of Blastomyces dermatitidis
http://phil.cdc.gov/PHIL_Images/497/497_lores.jpg



Dobell's iodine solution...sometimes used in the processing of fecal specimen microscopy slides,
especially when the identification of the
possible presence of parasitic cysts in the sample.
http://phil.cdc.gov/PHIL_Images/11248/11248_lores.jpg


Quality Control
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xlab_selection/xqa/qc

http://www.pepfar.gov/press/86519.htm
Building laboratory capacity: The U.S. President's Emergency Plan for AIDS Relief


Timing
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xlab_selection/xtiming2

[blood collection tubes ]
http://www.isips.org/Blood_collection_tubes_plastic.php


Field Logisitics
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xfield_logistics

Blood draw for genetic studies
http://www.ushersyndrome.nih.gov/join/blood.html

Specimen collection
http://cclnprod.cc.nih.gov/dlm/testguide.nsf/Index/9A7700DD8BE897D285256B990064B380?OpenDocument


Cold Chain
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xfield_logistics/xcold_chain

Dry Ice
http://www2a.cdc.gov/vaccines/ed/shtoolkit/pages/SH_plans.htm

Storage
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xfield_logistics/xinventory

CPC


Safe Handling
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xfield_logistics/xsafe_handling

Ammons
Cryogenic gloves used in subzero freezers


Specimen management
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xspecimen_management

Ammons
CPC -80° freezers
Freezer boxes

Refrigerated/frozen packs

http://www2a.cdc.gov/vaccines/ed/shtoolkit/pages/SH_plans.htm

Ethical issues associated with collecting biological specimens
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xethical_issues

Informed consent
http://www.nei.nih.gov/health/clinicaltrials_facts/#5

Medical waste
http://www.fedcenter.gov/assistance/facilitytour/solid/medical/


Equipment and supplies
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xordering_supplies

Selecting, Evaluating, and Using Sharps Disposal Containers
http://www.cdc.gov/niosh/sharps1.html


UNC & Vendors
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xordering_supplies/xvendors

Example of MMD codes
http://finance.unc.edu/material--disbursement-services/contract-services/mmd-statements.html


Biomarkers in the Literature
https://www.cpc.unc.edu/services/biomed/site_edit/temp/xcurrent_awareness

http://publications.nigms.nih.gov/thenewgenetics/chapter5.html#c1
Screen shot of GeneWays, a data mining tool used to scan research literature about changes in
genes and  proteins