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Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Citation

Saccone, Nancy L.; Emery, Leslie S.; Sofer, Tamar; Gogarten, Stephanie M.; Becker, Diane M.; Bottinger, Erwin P.; Chen, Li-Shiun; Culverhouse, Robert C.; Duan, Weimin; & Hancock, Dana B., et al. (2018). Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Nicotine & Tobacco Research, 20(4), 448-457. PMCID: PMC5896462

Abstract

Introduction: Genetic variants associated with nicotine dependence have previously been identified, primarily in European-ancestry populations. No genome-wide association studies (GWAS) have been reported for smoking behaviors in Hispanics/Latinos in the U.S. and Latin America, who are of mixed ancestry with European, African, and American Indigenous components.
Methods: We examined genetic associations with smoking behaviors in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) [N=12,741 with smoking data, 5,119 ever smokers], using ~2.3 million genotyped variants imputed to the 1000 Genomes Project phase 3. Mixed logistic regression models accounted for population structure, sampling, relatedness, sex, and age.
Results: The known region of CHRNA5, which encodes the alpha5 cholinergic nicotinic receptor subunit, was associated with heavy smoking at genome-wide significance (p 10 versus 3,156 reporting CPD Conclusions: Associations of nicotinic receptor gene variants with smoking, first reported in non-Hispanic European-ancestry populations, generalized to Hispanics/Latinos despite different patterns of smoking behavior.

URL

http://dx.doi.org/10.1093/ntr/ntx107

Reference Type

Journal Article

Year Published

2018

Journal Title

Nicotine & Tobacco Research

Author(s)

Saccone, Nancy L.
Emery, Leslie S.
Sofer, Tamar
Gogarten, Stephanie M.
Becker, Diane M.
Bottinger, Erwin P.
Chen, Li-Shiun
Culverhouse, Robert C.
Duan, Weimin
Hancock, Dana B.
Hosgood, H. Dean
Johnson, Eric O.
Loos, Ruth J. F.
Louie, Tin
Papanicolaou, George J.
Perreira, Krista M.
Rodriquez, Erik J.
Schurmann, Claudia
Stilp, Adrienne M.
Szpiro, Adam A.
Talavera, Gregory A.
Taylor, Kent D.
Thrasher, James F.
Yanek, Lisa R.
Laurie, Cathy C.
Perez-Stable, Eliseo J.
Bierut, Laura J.
Kaplan, Robert C.

PMCID

PMC5896462