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Transitions from Ideal to Intermediate Cholesterol Levels May Vary by Cholesterol Metric

Citation

Engeda, Joseph C.; Holliday, Katelyn M.; Hardy, Shakia T.; Chakladar, Sujatro; Lin, Dan-Yu; Talavera, Gregory A.; Howard, Barbara V.; Daviglus, Martha L.; Pirzada, Amber; & Schreiner, Pamela J., et al. (2018). Transitions from Ideal to Intermediate Cholesterol Levels May Vary by Cholesterol Metric. Scientific Reports, 8, 2782. PMCID: PMC5807429

Abstract

To examine the ability of total cholesterol (TC), a low-density lipoprotein cholesterol (LDL-C) proxy widely used in public health initiatives, to capture important population-level shifts away from ideal and intermediate LDL-C throughout adulthood. We estimated age (>/=20 years)-, race/ethnic (Caucasian, African American, and Hispanic/Latino)-, and sex- specific net transition probabilities between ideal, intermediate, and poor TC and LDL-C using National Health and Nutrition Examination Survey (2007-2014; N = 13,584) and Hispanic Community Health Study/Study of Latinos (2008-2011; N = 15,612) data in 2016 and validated and calibrated novel Markov-type models designed for cross-sectional data. At age 20, >80% of participants had ideal TC, whereas the race/ethnic- and sex-specific prevalence of ideal LDL-C ranged from 39.2%-59.6%. Net transition estimates suggested that the largest one-year net shifts away from ideal and intermediate LDL-C occurred approximately two decades earlier than peak net population shifts away from ideal and intermediate TC. Public health and clinical initiatives focused on monitoring TC in middle-adulthood may miss important shifts away from ideal and intermediate LDL-C, potentially increasing the duration, perhaps by decades, that large segments of the population are exposed to suboptimal LDL-C.

URL

http://dx.doi.org/10.1038/s41598-018-20660-2

Reference Type

Journal Article

Year Published

2018

Journal Title

Scientific Reports

Series Title

JC Engeda et al. Sci Rep 8 (1), 6238. 2018. PMID 29651142.

Author(s)

Engeda, Joseph C.
Holliday, Katelyn M.
Hardy, Shakia T.
Chakladar, Sujatro
Lin, Dan-Yu
Talavera, Gregory A.
Howard, Barbara V.
Daviglus, Martha L.
Pirzada, Amber
Schreiner, Pamela J.
Zeng, Donglin
Avery, Christy L.

PMCID

PMC5807429