Analytical and Biological Variability in Biomarker Measurement in the Hispanic Community Health Study/Study of Latinos

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Citation

Thyagarajan, Bharat; Howard, Annie Green; Durazo-Arvizu, Ramon A.; Eckfeldt, John H.; Gellman, Marc D.; Kim, Ryung S.; Liu, Kiang; Mendez, Armando J.; Penedo, Frank J.; & Talavera, Gregory A., et al. (2016). Analytical and Biological Variability in Biomarker Measurement in the Hispanic Community Health Study/Study of Latinos. Clinical Chimica Acta, 463, 129-137. PMCID: PMC5136507

Abstract

BACKGROUND: Biomarker variability, which includes within-individual variability (CVI), between-individual variability (CVG) and methodological variability (CVP+A) is an important determinant of our ability to detect biomarker-disease associations. Estimates of CVI and CVG may be population specific and little data exists on biomarker variability in diverse Hispanic populations. Hence, we evaluated all 3 components of biomarker variability in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) using repeat blood collections (n=58) and duplicate blood measurements (n=761-929 depending on the biomarker).
METHODS: We estimated the index of individuality (II) ((CVI+CVP+A)/CVG) for 41 analytes and evaluated differences in the II across sexes and age groups.
RESULTS: Biomarkers such as fasting glucose, triglycerides and ferritin had substantially higher inter-individual variability and lower II in HCHS/SOL as compared to the published literature. We also found significant sex-specific differences in the II for neutrophil count, platelet count, hemoglobin, % eosinophils and fasting glucose. The II for fasting insulin, post oral glucose tolerance test glucose and cystatin C was significantly higher among the 18-44y age group as compared to the 45+y age group.
CONCLUSIONS: The implications of these findings for determining biomarker-disease associations in Hispanic populations need to be evaluated in future studies.

URL

http://dx.doi.org/10.1016/j.cca.2016.10.019

Reference Type

Journal Article

Year Published

2016

Journal Title

Clinical Chimica Acta

Author(s)

Thyagarajan, Bharat
Howard, Annie Green
Durazo-Arvizu, Ramon A.
Eckfeldt, John H.
Gellman, Marc D.
Kim, Ryung S.
Liu, Kiang
Mendez, Armando J.
Penedo, Frank J.
Talavera, Gregory A.
Youngblood, Marston E.
Zhao, Lihui
Sotres-Alvarez, Daniela T.

PMCID

PMC5136507

ORCiD

Howard, AG - 0000-0003-0837-8166