CitationSimanek, Amanda M.; Zheng, Cheng; Yolken, Robert H.; Haan, Mary N.; & Aiello, Allison E. (2019). A Longitudinal Study of the Association between Persistent Pathogens and Incident Depression among Older US Latinos. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(5), 634-641. PMCID: PMC6477673
AbstractDepression is estimated to affect over 6.5 million Americans 65 years of age and older and compared to Non-Latino Whites older US Latinos have a greater incidence and severity of depression, warranting further investigation of novel risk factors for depression onset among this population. We used data on 771/1789 individuals >/= 60 years of age from the Sacramento Area Latino Study on Aging (1998-2008) who were tested for cytomegalovirus (CMV), herpes simplex virus, varicella zoster, Helicobacter pylori, Toxoplasma gondii, and C-reactive protein (CRP) and interleukin-6 (IL-6) level. Among those without elevated depressive symptoms at baseline, we examined the association between each pathogen, inflammatory markers and incident depression over up to approximately nine years of follow-up using discrete time logistic regression. We found that only CMV seropositivity was statistically significantly associated with increased odds of incident depression (odds ratio (OR) 1.38, 95% confidence interval (CI): 1.00, 1.90) in the total sample as well as among women only (OR 1.70, 95% CI: 1.01, 2.86). These associations were not mediated by CRP or IL-6 levels. Our findings suggest that CMV seropositivity may serve as an important risk factor for the onset of depression among older US Latinos, but act outside of inflammatory pathways.
Reference TypeJournal Article
Journal TitleJournals of Gerontology Series A: Biological Sciences and Medical Sciences
Author(s)Simanek, Amanda M.
Yolken, Robert H.
Haan, Mary N.
Aiello, Allison E.