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Epigenetic Meta-Analysis across Three Civilian Cohorts Identifies NRG1 and HGS as Blood-Based Biomarkers for Post-Traumatic Stress Disorder

Citation

Uddin, Monica; Ratanatharathorn, Andrew; Armstrong, Don; Kuan, Pei-Fen; Aiello, Allison E.; Bromet, Evelyn J.; Galea, Sandro; Koenen, Karestan C.; Luft, Benjamin J.; & Ressler, Kerry J., et al. (2018). Epigenetic Meta-Analysis across Three Civilian Cohorts Identifies NRG1 and HGS as Blood-Based Biomarkers for Post-Traumatic Stress Disorder. Epigenomics, 10(12), 1585-1601. PMCID: PMC6331697

Abstract

AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.
MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.
RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).
CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

URL

http://dx.doi.org/10.2217/epi-2018-0049

Reference Type

Journal Article

Year Published

2018

Journal Title

Epigenomics

Author(s)

Uddin, Monica
Ratanatharathorn, Andrew
Armstrong, Don
Kuan, Pei-Fen
Aiello, Allison E.
Bromet, Evelyn J.
Galea, Sandro
Koenen, Karestan C.
Luft, Benjamin J.
Ressler, Kerry J.
Wildman, Derek E.
Nievergelt, Caroline M.
Smith, Alicia K.

PMCID

PMC6331697