Interethnic Analyses of Blood Pressure Loci in Populations of East Asian and European Descent

Citation

Takeuchi, Fumihiko; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohiro; Nakatochi, Masahiro; Tabara, Yasuharu; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; & Spracklen, Cassandra N., et al. (2018). Interethnic Analyses of Blood Pressure Loci in Populations of East Asian and European Descent. Nature Communications, 9, 5052. PMCID: PMC6261994

Abstract

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

URL

http://dx.doi.org/10.1038/s41467-018-07345-0

Reference Type

Journal Article

Year Published

2018

Journal Title

Nature Communications

Author(s)

Takeuchi, Fumihiko
Akiyama, Masato
Matoba, Nana
Katsuya, Tomohiro
Nakatochi, Masahiro
Tabara, Yasuharu
Narita, Akira
Saw, Woei-Yuh
Moon, Sanghoon
Spracklen, Cassandra N.
Chai, Jin Fang
Kim, Young Jin
Zhang, Liang
Wang, Chaolong
Li, Huaixing
Li, Honglan
Wu, Jer-Yuarn
Dorajoo, Rajkumar
Nierenberg, Jovia L.
Wang, Ya Xing
He, Jing
Bennett, Derrick A.
Takahashi, Atsushi
Momozawa, Yukihide
Hirata, Makoto
Matsuda, Koichi
Rakugi, Hiromi
Nakashima, Eitaro
Isono, Masato
Shirota, Matsuyuki
Hozawa, Atsushi
Ichihara, Sahoko
Matsubara, Tatsuaki
Yamamoto, Ken
Kohara, Katsuhiko
Igase, Michiya
Han, Sohee
Gordon-Larsen, Penny
Huang, Wei
Lee, Nanette R.
Adair, Linda S.
Hwang, Mi Yeong
Lee, Juyoung
Chee, Miao Li
Sabanayagam, Charumathi
Zhao, Wanting
Liu, Jianjun
Reilly, Dermot F.
Sun, Liang
Huo, Shaofeng
Edwards, Todd L.
Long, Jirong
Chang, Li-Ching
Chen, Chien-Hsiun
Yuan, Jian-Min
Koh, Woon-Puay
Friedlander, Yechiel
Kelly, Tanika N.
Bin Wei, Wen
Xu, Liang
Cai, Hui
Xiang, Yong-Bing
Lin, Kuang
Clarke, Robert
Walters, Robin G.
Millwood, Iona Y.
Li, Liming
Chambers, John C.
Kooner, Jaspal Singh S.
Elliott, Paul
van der Harst, Pim
International Genomics of Blood Pressure (iGEN-BP) Consortium,
Chen, Zhengming
Sasaki, Makoto
Shu, Xiao-Ou
Jonas, Jost B.
He, Jiang
Heng, Chew-Kiat
Chen, Yuan-Tsong
Zheng, Wei
Lin, Xu
Teo, Yik Ying
Tai, E. Shyong
Cheng, Ching-Yu
Wong, Tien Yin
Sim, Xueling
Mohlke, Karen L.
Yamamoto, Masayuki
Kim, Bong-Jo
Miki, Tetsuro
Nabika, Toru
Yokota, Mitsuhiro
Kamatani, Yoichiro
Kubo, Michiaki
Kato, Norihiro

PMCID

PMC6261994

ORCiD

Gordon-Larsen - 0000-0001-5322-4188
Adair - 0000-0002-3670-8073