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Environmental Modifiers of RTS,S/AS01 Malaria Vaccine Efficacy in Lilongwe, Malawi

Citation

Bell, Griffin J.; Loop, Matthew S.; Mvalo, Tisungane; Juliano, Jonathan J.; Mofolo, Innocent A.; Kamthunzi, Portia; Tegha, Gerald; Lievens, Marc; Bailey, Jeffrey A.; & Emch, Michael E., et al. (2020). Environmental Modifiers of RTS,S/AS01 Malaria Vaccine Efficacy in Lilongwe, Malawi. BMC Public Health, 20(1), 910. PMCID: PMC7291743

Abstract

BACKGROUND: RTS,S/AS01 is the first vaccine against malaria to undergo pilot implementation, beginning in 2019 and vaccinating 360,000 children per year in Malawi, Ghana, and Kenya. The four-dose vaccine is given as a primary three-dose series with a fourth dose given approximately 18 months later. The efficacy of RTS,S/AS01 was variable among the 11 sites participating in the 2009-2014 phase III trial (MALARIA-055, NCT00866619), possibly due to differences in transmission intensity. However, a within-site examination of environmental factors related to transmission intensity and their impact on vaccine efficacy has yet to be conducted.

URL

http://dx.doi.org/10.1186/s12889-020-09039-z

Reference Type

Journal Article

Journal Title

BMC Public Health

Author(s)

Bell, Griffin J.
Loop, Matthew S.
Mvalo, Tisungane
Juliano, Jonathan J.
Mofolo, Innocent A.
Kamthunzi, Portia
Tegha, Gerald
Lievens, Marc
Bailey, Jeffrey A.
Emch, Michael E.
Hoffman, Irving F.

Year Published

2020

Volume Number

20

Issue Number

1

Pages

910

PMCID

PMC7291743

Reference ID

12789