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Impact of Substandard and Falsified Antimalarials in Zambia: Application of the SAFARI Model

Citation

Jackson, Kathryn D.; Higgins, Colleen R.; Laing, Sarah K.; Mwila, Chiluba; Kobayashi, Tamaki; Ippolito, Matthew M.; Sylvia, Sean; & Ozawa, Sachiko (2020). Impact of Substandard and Falsified Antimalarials in Zambia: Application of the SAFARI Model. BMC Public Health, 20(1), 1083. PMCID: PMC7350731

Abstract

BACKGROUND: Many countries are striving to become malaria-free, but global reduction in case estimates has stagnated in recent years. Substandard and falsified medicines may contribute to this lack of progress. Zambia aims to eliminate their annual burden of 1.2 million pediatric malaria cases and 2500 child deaths due to malaria. We examined the health and economic impact of poor-quality antimalarials in Zambia.
METHODS: An agent-based model, Substandard and Falsified Antimalarial Research Impact (SAFARI), was modified and applied to Zambia. The model was developed to simulate population characteristics, malaria incidence, patient care-seeking, disease progression, treatment outcomes, and associated costs of malaria for children under age five. Zambia-specific demographic, epidemiological, and cost inputs were extracted from the literature. Simulations were run to estimate the health and economic impact of poor-quality antimalarials, the effect of potential artemisinin resistance, and six additional malaria focused policy interventions.
RESULTS: We simulated annual malaria cases among Zambian children under five. At baseline, we found 2610 deaths resulting in $141.5 million in annual economic burden of malaria. We estimated that elimination of substandard and falsified antimalarials would result in an 8.1% (n = 213) reduction in under-five deaths, prevent 937 hospitalizations, and realize $8.5 million in economic savings, annually. Potential artemisinin resistance could further increase deaths by 6.3% (n = 166) and cost an additional $9.7 million every year.
CONCLUSIONS: Eliminating substandard and falsified antimalarials is an important step towards a malaria-free Zambia. Beyond the dissemination of insecticide-treated bed nets, indoor residual spraying, and other malaria control measures, attention must also be paid to assure the quality of antimalarial treatments.

URL

http://dx.doi.org/10.1186/s12889-020-08852-w

Reference Type

Journal Article

Article Type

Regular

Year Published

2020

Journal Title

BMC Public Health

Author(s)

Jackson, Kathryn D.
Higgins, Colleen R.
Laing, Sarah K.
Mwila, Chiluba
Kobayashi, Tamaki
Ippolito, Matthew M.
Sylvia, Sean
Ozawa, Sachiko

PMCID

PMC7350731

Continent/Country

Zambia