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Dietary Glycaemic Index, Glycaemic Load and Head and Neck Cancer Risk: A Pooled Analysis in an International Consortium

Citation

Chang, Chun-Pin; La Vecchia, Carlo; Serraino, Diego; Olshan, Andrew F.; Zevallos, Jose P.; Morgenstern, Hal; Levi, Fabio; Garavello, Werner; Kelsey, Karl T.; & McClean, Michael D., et al. (2020). Dietary Glycaemic Index, Glycaemic Load and Head and Neck Cancer Risk: A Pooled Analysis in an International Consortium. British Journal of Cancer, 122(6), 745-8. PMCID: PMC7078183

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR(Q4 vs. Q1) = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (OR(Q4 vs. Q1) = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (OR(Q4 vs. Q1) = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

URL

http://dx.doi.org/10.1038/s41416-019-0702-4

Reference Type

Journal Article

Journal Title

British Journal of Cancer

Author(s)

Chang, Chun-Pin
La Vecchia, Carlo
Serraino, Diego
Olshan, Andrew F.
Zevallos, Jose P.
Morgenstern, Hal
Levi, Fabio
Garavello, Werner
Kelsey, Karl T.
McClean, Michael D.
Chen, Chu
Schwartz, Stephen M.
Schantz, Stimson
Yu, Guo-Pei
Boffetta, Paolo
Hashibe, Mia
Lee, Yuan-Chin Amy
Parpinel, Maria
Augustin, Livia S. A.
Turati, Federica
Zhang, Zuo-Feng
Edefonti, Valeria

Year Published

2020

Volume Number

122

Issue Number

6

Pages

745-8

PMCID

PMC7078183

Reference ID

13063