Citation
Chang, Chun-Pin; La Vecchia, Carlo; Serraino, Diego; Olshan, Andrew F.; Zevallos, Jose P.; Morgenstern, Hal; Levi, Fabio; Garavello, Werner; Kelsey, Karl T.; & McClean, Michael D., et al. (2020). Dietary Glycaemic Index, Glycaemic Load and Head and Neck Cancer Risk: A Pooled Analysis in an International Consortium. British Journal of Cancer, 122(6), 745-748. PMCID: PMC7078183Abstract
High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR(Q4 vs. Q1) = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (OR(Q4 vs. Q1) = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (OR(Q4 vs. Q1) = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.URL
http://dx.doi.org/10.1038/s41416-019-0702-4Reference Type
Journal ArticleYear Published
2020Journal Title
British Journal of CancerAuthor(s)
Chang, Chun-PinLa Vecchia, Carlo
Serraino, Diego
Olshan, Andrew F.
Zevallos, Jose P.
Morgenstern, Hal
Levi, Fabio
Garavello, Werner
Kelsey, Karl T.
McClean, Michael D.
Chen, Chu
Schwartz, Stephen M.
Schantz, Stimson
Yu, Guo-Pei
Boffetta, Paolo
Hashibe, Mia
Lee, Yuan-Chin Amy
Parpinel, Maria
Augustin, Livia S. A.
Turati, Federica
Zhang, Zuo-Feng
Edefonti, Valeria