Joint Effects of Intensity and Duration of Cigarette Smoking on the Risk of Head and Neck Cancer: A Bivariate Spline Model Approach

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Di Credico, Gioia; Edefonti, Valeria; Polesel, Jerry; Pauli, Francesco; Torelli, Nicola; Serraino, Diego; Negri, Eva; Luce, Daniele; Stucker, Isabelle; & Matsuo, Keitaro, et al. (2019). Joint Effects of Intensity and Duration of Cigarette Smoking on the Risk of Head and Neck Cancer: A Bivariate Spline Model Approach. Oral Oncology, 94, 47-57. PMCID: PMC7117823

Abstract

OBJECTIVES: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.
MATERIALS AND METHODS: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.
RESULTS: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of

URL

http://dx.doi.org/10.1016/j.oraloncology.2019.05.006

Reference Type

Journal Article

Year Published

2019

Journal Title

Oral Oncology

Author(s)

Di Credico, Gioia
Edefonti, Valeria
Polesel, Jerry
Pauli, Francesco
Torelli, Nicola
Serraino, Diego
Negri, Eva
Luce, Daniele
Stucker, Isabelle
Matsuo, Keitaro
Brennan, Paul
Vilensky, Marta
Fernandez, Leticia
Curado, Maria Paula
Menezes, Ana M.
Daudt, Alexander W.
Koifman, Rosalina
Wunsch-Filho, Victor
Holcatova, Ivana
Ahrens, Wolfgang
Lagiou, Pagona
Simonato, Lorenzo
Richiardi, Lorenzo
Healy, Claire M.
Kjaerheim, Kristina
Conway, David I.
Macfarlane, Tatiana V.
Thomson, Peter
Agudo, Antonio
Znaor, Ariana
Boaventura Rios, Leonardo F.
Toporcov, Tatiana N.
Franceschi, Silvia
Herrero, Rolando
Muscat, Joshua E.
Olshan, Andrew F.
Zevallos, Jose P.
La Vecchia, Carlo
Winn, Deborah M.
Sturgis, Erich M.
Li, Guojun
Fabianova, Eleonora
Lissowska, Jolanta
Mates, Dana
Rudnai, Peter
Shangina, Oxana
Swiatkowska, Beata
Moysich, Kirsten
Zhang, Zuo-Feng
Morgenstern, Hal
Levi, Fabio
Smith, Elaine
Lazarus, Philip
Bosetti, Cristina
Garavello, Werner
Kelsey, Karl T.
McClean, Michael D.
Ramroth, Heribert
Chen, Chu
Schwartz, Stephen M.
Vaughan, Thomas L.
Zheng, Tongzhang
Menvielle, Gwenn
Boccia, Stefania
Cadoni, Gabriella
Hayes, Richard B.
Purdue, Mark P.
Gillison, Maura L.
Schantz, Stimson
Yu, Guo-Pei
Brenner, Hermann
D'Souza, Gypsyamber
Gross, Neil D. D.
Chuang, Shu-Chun
Boffetta, Paolo
Hashibe, Mia
Lee, Yuan-Chin Amy
Dal Maso, Luigino

PMCID

PMC7117823

ORCiD

Olshan - 0000-0001-9115-5128