Menu Close

The PrEPARE Pretoria Project: Protocol for a Cluster-Randomized Factorial-Design Trial to Prevent HIV with PrEP among Adolescent Girls and Young Women in Tshwane, South Africa

Citation

Wechsberg, Wendee M.; Browne, Felicia A.; Ndirangu, Jacqueline W.; Bonner, Courtney Peasant; Minnis, Alexandra M.; Nyblade, Laura; Speizer, Ilene S.; Howard, Brittni N.; Myers, Bronwyn; & Ahmed, Khatija (2020). The PrEPARE Pretoria Project: Protocol for a Cluster-Randomized Factorial-Design Trial to Prevent HIV with PrEP among Adolescent Girls and Young Women in Tshwane, South Africa. BMC Public Health, 20(1), 1403. PMCID: PMC7490774

Abstract

BACKGROUND: Despite increased prevention efforts, HIV remains the leading cause of death among adolescent girls and young women in South Africa. Although research indicates important determinants of HIV acquisition at the individual and interpersonal levels, structural-level stigma and discrimination continue to be critical barriers to reaching and retaining this key population for HIV prevention and sexual and reproductive health services. Innovative and multilevel interventions are needed that can address the intersectional structural and gender issues that young women face, including stigma, alcohol and drug use, gender-based violence, and other risk factors when seeking health services. Oral pre-exposure prophylaxis (PrEP) taken daily has been found to be an effective biomedical HIV prevention tool. Testing a comprehensive gender-focused biobehavioral HIV prevention intervention that is inclusive of social ecological determinants, such as stigma and discrimination reduction in clinics, is critical for reducing HIV among adolescent girls and young women.

URL

http://dx.doi.org/10.1186/s12889-020-09458-y

Reference Type

Journal Article

Journal Title

BMC Public Health

Author(s)

Wechsberg, Wendee M.
Browne, Felicia A.
Ndirangu, Jacqueline W.
Bonner, Courtney Peasant
Minnis, Alexandra M.
Nyblade, Laura
Speizer, Ilene S.
Howard, Brittni N.
Myers, Bronwyn
Ahmed, Khatija

Year Published

2020

Volume Number

20

Issue Number

1

Pages

1403

PMCID

PMC7490774

Reference ID

13123