Genetic Variants in Anti-Müllerian Hormone-Related Genes and Breast Cancer Risk: Results from the AMBER Consortium

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Citation

Nichols, Hazel B.; Graff, Mariaelisa; Bensen, Jeannette T.; Lunetta, Kathryn L.; O'Brien, Katie M.; Troester, Melissa A.; Williams, Lindsay A.; Young, Kristin L.; Hong, Chi-Chen; & Yao, Song, et al. (2021). Genetic Variants in Anti-Müllerian Hormone-Related Genes and Breast Cancer Risk: Results from the AMBER Consortium. Breast Cancer Research and Treatment, 185(2), 469-478. PMCID: PMC7867570

Abstract

PURPOSE: Circulating anti-Müllerian hormone (AMH) levels are positively associated with time to menopause and breast cancer risk. We examined breast cancer associations with single nucleotide polymorphisms (SNPs) in the AMH gene or its receptor genes, ACVR1 and AMHR2, among African American women.
METHODS: In the AMBER consortium, we tested 65 candidate SNPs, and 1130 total variants, in or near AMH, ACVR1, and AMHR2 and breast cancer risk. Overall, 3649 cases and 4230 controls contributed to analyses. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer were calculated using multivariable logistic regression.
RESULTS: After correction for multiple comparisons (false-discovery rate of 5%), there were no statistically significant associations with breast cancer risk. Without correction for multiple testing, four candidate SNPs in ACVR1 and one near AMH were associated with breast cancer risk. In ACVR1, rs13395576[C] was associated with lower breast cancer risk overall (OR 0.84; 95% CI 0.72, 0.97) and for ER+ disease (OR 0.75; CI 0.62, 0.89) (p < 0.05). Rs1220110[A] and rs1220134[T] each had ORs of 0.89-0.90 for postmenopausal and ER+ breast cancer (p 

URL

http://dx.doi.org/10.1007/s10549-020-05944-4

Reference Type

Journal Article

Year Published

2021

Journal Title

Breast Cancer Research and Treatment

Author(s)

Nichols, Hazel B.
Graff, Mariaelisa
Bensen, Jeannette T.
Lunetta, Kathryn L.
O'Brien, Katie M.
Troester, Melissa A.
Williams, Lindsay A.
Young, Kristin L.
Hong, Chi-Chen
Yao, Song
Haiman, Christopher A.
Ruiz-Narváez, Edward A.
Ambrosone, Christine B.
Palmer, Julie R.
Olshan, Andrew F.

Article Type

Regular

PMCID

PMC7867570

Data Set/Study

African American Breast Cancer Epidemiology and Risk (AMBER) Consortium

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

African-American

Sex/Gender

Women

ORCiD

Olshan - 0000-0001-9115-5128
Graff - 0000-0001-6380-1735