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Cross-sectional and Prospective Associations between Sleep Regularity and Metabolic Health in the Hispanic Community Health Study/Study of Latinos

Citation

Fritz, Josef; Phillips, Andrew J. K.; Hunt, Larissa C.; Imam, Akram; Reid, Kathryn J.; Perreira, Krista M.; Mossavar-Rahmani, Yasmin; Daviglus, Martha L.; Sotres-Alvarez, Daniela T.; & Zee, Phyllis C., et al. (Online ahead of print). Cross-sectional and Prospective Associations between Sleep Regularity and Metabolic Health in the Hispanic Community Health Study/Study of Latinos. Sleep. PMCID: PMC Journal - In Process

Abstract

STUDY OBJECTIVES: Sleep is an emergent, multi-dimensional risk factor for diabetes. Sleep duration, timing, quality, and insomnia have been associated with diabetes risk and glycemic biomarkers, but the role of sleep regularity in the development of metabolic disorders is less clear.
METHODS: We analyzed data from 2,107 adults, aged 19-64 years, from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos, followed over a mean of 5.7 years. Multivariable-adjusted complex survey regression methods were used to model cross-sectional and prospective associations between the sleep regularity index (SRI) in quartiles (Q1-least regular, Q4-most regular) and diabetes (either laboratory-confirmed or self-reported antidiabetic medication use), baseline levels of insulin resistance (HOMA-IR), beta cell function (HOMA-β), hemoglobin A1c (HbA1c), and their changes over time.
RESULTS: Cross-sectionally, lower SRI was associated with higher odds of diabetes (odds ratio (OR)Q1 vs. Q4=1.64, 95%CI: 0.98-2.74, ORQ2 vs. Q4=1.12, 95%CI: 0.70-1.81, ORQ3 vs. Q4=1.00, 95%CI: 0.62-1.62, ptrend=0.023). The SRI effect was more pronounced in older (aged ≥45 years) adults (ORQ1 vs. Q4=1.88, 95%CI: 1.14-3.12, pinteraction=0.060) compared to younger ones. No statistically significant associations were found between SRI and diabetes incidence, as well as baseline HOMA-IR, HOMA-β, and HbA1c values, or their changes over time among adults not taking antidiabetic medication.
CONCLUSIONS: Our results suggest that sleep regularity represents another sleep dimension relevant for diabetes risk. Further research is needed to elucidate the relative contribution of sleep regularity to metabolic dysregulation and pathophysiology.

URL

http://dx.doi.org/10.1093/sleep/zsaa218

Reference Type

Journal Article

Article Type

Regular

Year Published

Online ahead of print

Journal Title

Sleep

Author(s)

Fritz, Josef
Phillips, Andrew J. K.
Hunt, Larissa C.
Imam, Akram
Reid, Kathryn J.
Perreira, Krista M.
Mossavar-Rahmani, Yasmin
Daviglus, Martha L.
Sotres-Alvarez, Daniela T.
Zee, Phyllis C.
Patel, Sanjay R.
Vetter, Céline

PMCID

PMC Journal - In Process

Data Set/Study

Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Hispanic/Latinx