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APOE Alleles’ Association with Cognitive Function Differs across Hispanic/Latino Groups and Genetic Ancestry in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL)

Citation

Granot-Hershkovitz, Einat; Tarraf, Wassim; Kurniansyah, Nuzulul; Daviglus, Martha L.; Isasi, Carmen R.; Kaplan, Robert C.; Lamar, Melissa; Perreira, Krista M.; Wassertheil-Smoller, Sylvia; & Stickel, Ariana, et al. (Online ahead of print). APOE Alleles' Association with Cognitive Function Differs across Hispanic/Latino Groups and Genetic Ancestry in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL). Alzheimer's & Dementia. PMCID: PMC Journal - In Process

Abstract

INTRODUCTION: Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.

URL

http://dx.doi.org/10.1002/alz.12205

Reference Type

Journal Article

Journal Title

Alzheimer's & Dementia

Author(s)

Granot-Hershkovitz, Einat
Tarraf, Wassim
Kurniansyah, Nuzulul
Daviglus, Martha L.
Isasi, Carmen R.
Kaplan, Robert C.
Lamar, Melissa
Perreira, Krista M.
Wassertheil-Smoller, Sylvia
Stickel, Ariana
Thyagarajan, Bharat
Zeng, Donglin
Fornage, Myriam
DeCarli, Charles S.
González, Hector M.
Sofer, Tamar

Year Published

Online ahead of print

PMCID

PMC Journal - In Process

Reference ID

13291