CitationKurtzman, James T.; Thorp, John M., Jr.; Spielman, Fred J.; Mueller, Robert A.; & Cefalo, Robert C. (1994). Central Hemodynamic Effects of Cocaine and Ritodrine in the Isolated, Perfused Rat Heart. Obstetrics & Gynecology, 83(1), 89-91.
AbstractOBJECTIVE: To explore the cardiac interactions of cocaine and ritodrine in pregnancy.
METHODS: Using the isolated, perfused rat-heart model, hearts from pregnant Sprague-Dawley rats were exposed to increasing concentrations of ritodrine: 25, 50, 100, and 250 ng/mL. Hearts of half of the animals, the experimental group, were exposed to cocaine (5 x 10(-6) mol/L). Left ventricular systolic pressure, heart rate, and contractility were measured.
RESULTS: Ritodrine had marked positive inotropic and chronotropic effects. Cocaine exposure resulted in smaller increases in all indices.
CONCLUSION: Cocaine blunted but did not obliterate the cardiac stimulatory effects of ritodrine in this model.
Reference TypeJournal Article
Journal TitleObstetrics & Gynecology
Author(s)Kurtzman, James T.
Thorp, John M., Jr.
Spielman, Fred J.
Mueller, Robert A.
Cefalo, Robert C.