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Central Hemodynamic Effects of Cocaine and Ritodrine in the Isolated, Perfused Rat Heart

Citation

Kurtzman, James T.; Thorp, John M., Jr.; Spielman, Fred J.; Mueller, Robert A.; & Cefalo, Robert C. (1994). Central Hemodynamic Effects of Cocaine and Ritodrine in the Isolated, Perfused Rat Heart. Obstetrics & Gynecology, 83(1), 89-91.

Abstract

OBJECTIVE: To explore the cardiac interactions of cocaine and ritodrine in pregnancy.
METHODS: Using the isolated, perfused rat-heart model, hearts from pregnant Sprague-Dawley rats were exposed to increasing concentrations of ritodrine: 25, 50, 100, and 250 ng/mL. Hearts of half of the animals, the experimental group, were exposed to cocaine (5 x 10(-6) mol/L). Left ventricular systolic pressure, heart rate, and contractility were measured.
RESULTS: Ritodrine had marked positive inotropic and chronotropic effects. Cocaine exposure resulted in smaller increases in all indices.
CONCLUSION: Cocaine blunted but did not obliterate the cardiac stimulatory effects of ritodrine in this model.

URL

https://journals.lww.com/greenjournal/abstract/1994/01000/central_hemodynamic_effects_of_cocaine_and.17.aspx

Reference Type

Journal Article

Year Published

1994

Journal Title

Obstetrics & Gynecology

Author(s)

Kurtzman, James T.
Thorp, John M., Jr.
Spielman, Fred J.
Mueller, Robert A.
Cefalo, Robert C.