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Pregnancy-Induced Hypertension: Genesis of and Response to Endothelial Injury and the Role of Endothelin 1

Citation

Rogers, Ronald G. & Thorp, John M., Jr. (1997). Pregnancy-Induced Hypertension: Genesis of and Response to Endothelial Injury and the Role of Endothelin 1. Obstetrics & Gynecological Survey, 52(12), 723-727.

Abstract

This paper discusses the spectrum of pregnancy-induced hypertension and presents a theory for its etiology. Endothelial injury is the purported precursor to pregnancy-induced hypertensive disorders, and this discussion expands on a possible mechanism by which injury could occur as a result of incomplete trophoblastic invasion. We review endothelin physiology and compare and contrast the evidence surrounding endothelin 1 as a putative mediator of PIH. An approach to treatment utilizing antagonists to the endothelin 1 receptor is introduced.

URL

http://dx.doi.org/10.1097/00006254-199712000-00002

Reference Type

Journal Article

Year Published

1997

Journal Title

Obstetrics & Gynecological Survey

Author(s)

Rogers, Ronald G.
Thorp, John M., Jr.