CitationRogers, Ronald G. & Thorp, John M., Jr. (1997). Pregnancy-Induced Hypertension: Genesis of and Response to Endothelial Injury and the Role of Endothelin 1. Obstetrics & Gynecological Survey, 52(12), 723-727.
AbstractThis paper discusses the spectrum of pregnancy-induced hypertension and presents a theory for its etiology. Endothelial injury is the purported precursor to pregnancy-induced hypertensive disorders, and this discussion expands on a possible mechanism by which injury could occur as a result of incomplete trophoblastic invasion. We review endothelin physiology and compare and contrast the evidence surrounding endothelin 1 as a putative mediator of PIH. An approach to treatment utilizing antagonists to the endothelin 1 receptor is introduced.
Reference TypeJournal Article
Journal TitleObstetrics & Gynecological Survey
Author(s)Rogers, Ronald G.
Thorp, John M., Jr.