Risk Factors for Healthcare Personnel Infection with Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT)

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Citation

Cummings, Derek A. T.; Radonovich, Lewis J., Jr.; Gorse, Geoffrey J.; Gaydos, Charlotte A.; Bessesen, Mary T.; Brown, Alexandria C.; Gibert, Cynthia L.; Hitchings, Matthew D. T.; Lessler, Justin; & Nyquist, Ann-Christine, et al. (2021). Risk Factors for Healthcare Personnel Infection with Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT). Clinical Infectious Diseases, 73(11), e4428-32. PMCID: PMC7454439

Abstract

BACKGROUND: SARS-CoV-2 presents a large risk to healthcare personnel. Quantifying the risk of coronavirus infection associated with workplace activities is an urgent need.
METHODS: We assessed the association of worker characteristics, occupational roles and behaviors, and participation in procedures with the risk of endemic coronavirus infection among healthcare personnel who participated in the Respiratory Protection Effectiveness Trial (ResPECT), a cluster randomized trial to assess personal protective equipment to prevent respiratory infections and illness conducted from 2011 to 2016.
RESULTS: Among 4,689 HCP-seasons, we detected coronavirus infection in 387 (8%). HCP who participated in an aerosol generation procedure (AGP) at least once during the viral respiratory season were 105% (95% CI 21%, 240%) more likely to be diagnosed with a laboratory-confirmed coronavirus infection. Younger individuals, those who saw pediatric patients and those with household members under the age of five were at increased risk of coronavirus infection.
CONCLUSIONS: Our analysis suggests the risk of HCP becoming infected with an endemic coronavirus increases approximately two-fold with exposures to AGP. Our findings may be relevant to the Coronavirus Disease 2019 (COVID-19) pandemic; however, SARS-COV-2, the virus that causes COVID-19, may differ from endemic coronaviruses in important ways.

URL

http://dx.doi.org/10.1093/cid/ciaa900

Reference Type

Journal Article

Year Published

2021

Journal Title

Clinical Infectious Diseases

Author(s)

Cummings, Derek A. T.
Radonovich, Lewis J., Jr.
Gorse, Geoffrey J.
Gaydos, Charlotte A.
Bessesen, Mary T.
Brown, Alexandria C.
Gibert, Cynthia L.
Hitchings, Matthew D. T.
Lessler, Justin
Nyquist, Ann-Christine
Rattigan, Susan M.
Rodriguez-Barradas, Maria C.
Price, Connie Savor
Reich, Nicholas G.
Simberkoff, Michael S.
Perl, Trish M.

Article Type

Regular

PMCID

PMC7454439

Data Set/Study

Respiratory Protection Effectiveness Clinical Trial (ResPECT)

Continent/Country

United States of America

State

Nonspecific

ORCiD

Lessler - 0000-0002-9741-8109