Citation
Park, Hanla A.; Neumeyer, Sonja; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; & Antonenkova, Natalia N., et al. (2021). Mendelian Randomisation Study of Smoking Exposure in Relation to Breast Cancer Risk. British Journal of Cancer, 125(8), 1135-1145. PMCID: PMC8505411Abstract
BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk.METHODS: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.
RESULTS: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10(-2)), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect.
CONCLUSION: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
URL
http://dx.doi.org/10.1038/s41416-021-01432-8Reference Type
Journal ArticleYear Published
2021Journal Title
British Journal of CancerAuthor(s)
Park, Hanla A.Neumeyer, Sonja
Michailidou, Kyriaki
Bolla, Manjeet K.
Wang, Qin
Dennis, Joe
Ahearn, Thomas U.
Andrulis, Irene L.
Anton-Culver, Hoda
Antonenkova, Natalia N.
Arndt, Volker
Aronson, Kristan J.
Augustinsson, Annelie
Baten, Adinda
Beane Freeman, Laura E.
Becher, Heiko
Beckmann, Matthias W.
Behrens, Sabine
Benitez, Javier
Bermisheva, Marina
Bogdanova, Natalia V.
Bojesen, Stig Egil
Brauch, Hiltrud
Brenner, Hermann
Brucker, Sara Y.
Burwinkel, Barbara
Campa, Daniele
Canzian, Federico
Castelao, Jose E.
Chanock, Stephen J.
Chenevix-Trench, Georgia
Clarke, Christine L.
NBCS Collaborators,
Conroy, Don M.
Couch, Fergus J.
Cox, Angela
Cross, Simon S.
Czene, Kamila
Daly, Mary B.
Devilee, Peter
Dörk, Thilo
Dos-Santos-Silva, Isabel
Dwek, Miriam
Eccles, Diana M.
Eliassen, A. Heather
Engel, Christoph
Eriksson, Mikael
Evans, D. Gareth
Fasching, Peter A.
Flyger, Henrik
Fritschi, Lin
García-Closas, Montserrat
García-Sáenz, José A.
Gaudet, Mia M.
Giles, Graham G.
Glendon, Gord
Goldberg, Mark S.
Goldgar, David E.
González-Neira, Anna
Grip, Mervi
Guénel, Pascal
Hahnen, Eric
Haiman, Christopher A.
Håkansson, Niclas
Hall, Per
Hamann, Ute
Han, Sileny N.
Harkness, Elaine F.
Hart, Steven N.
He, Wei
Heemskerk-Gerritsen, Bernadette A. M.
Hopper, John L.
Hunter, David J.
ABCTB Investigators,
kConFab Investigators,
Jager, Agnes
Jakubowska, Anna
John, Esther M.
Jung, Audrey
Kaaks, Rudolf
Kapoor, Pooja Middha
Keeman, Renske
Khusnutdinova, Elza
Kitahara, Cari M.
Koppert, Linetta B.
Koutros, Stella
Kristensen, Vessela N.
Kurian, Allison W.
Lacey, James V.
Lambrechts, Diether
Le Marchand, Loic
Lo, Wing-Yee
Lubi
ński, Jan
Mannermaa, Arto
Manoochehri, Mehdi
Margolin, Sara
Martinez, Maria Elena
Mavroudis, Dimitrios
Meindl, Alfons
Menon, Usha
Milne, Roger L
.
Muranen, Taru A
.
Nevanlinna, Heli
Newman, William G
.
Nordestgaard, Børge G
.
Offit, Kenneth
Olshan, Andrew F
.
Olsson, Håkan
Park-Simon, Tjoung-Won
Peterlongo, Paolo
Peto, Julian
Plaseska-Karanfilska, Dijana
Presneau, Nadege
Radice, Paolo
Rennert, Gad
Rennert, Hedy S
.
Romero, Atocha
Saloustros, Emmanouil
Sawyer, Elinor J
.
Schmidt, Marjanka K
.
Schmutzler, Rita K
.
Schoemaker, Minouk J
.
Schwentner, Lukas
Scott, Christopher
Shah, Mitul
Shu, Xiao-Ou
Simard, Jacques
Smeets, Ann
Southey, Melissa C
.
Spinelli, John J
.
Stevens, Victoria
L.
Swerdlow, Anthony J
.
Tamimi, Rulla M
.
Tapper, William J
.
Taylor, Jack A
.
Terry, Mary Beth
Tomlinson, Ian
Troester, Melissa A
.
Truong, Thérèse
Vachon, Celine M
.
van Veen, Elke M
.
Vijai, Joseph
Wang, Sophia
S.
Wendt, Camilla
Winqvist, Robert
Wolk, Alicja
Ziogas, Argyrios
Dunning, Alison M
.
Pharoah, Paul D
.
P
.
Easton, Douglas F
.
Zheng, Wei
Kraft, Peter
Chang-Claude, Jenny