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The Association of Stress, Metabolic Syndrome and Systemic Inflammation with Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and Its Sociocultural Ancillary Study

Citation

Marquine, María J.; Gallo, Linda C.; Tarraf, Wassim; Wu, Benson; Moore, Alison A.; Vásquez, Priscilla M.; Talavera, Gregory; Allison, Matthew; Muñoz, Elizabeth; & Isasi, Carmen R., et al. (Online ahead of print). The Association of Stress, Metabolic Syndrome and Systemic Inflammation with Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and Its Sociocultural Ancillary Study. Journals of Gerontology Series B: Psychological Sciences and Social Sciences. PMCID: PMC Journal - In Process

Abstract

OBJECTIVES: Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer's disease and related dementias. We examined cross-sectional associations between stress and neurocognition, and the role that metabolic syndrome (MetS) and systemic inflammation might play in these associations.
METHOD: Participants included 3,045 adults aged 45-75 (56% female, education 0-20+ years, 86% Spanish-speaking, 23% US born), enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and its Sociocultural Ancillary Study. Global neurocognition was the primary outcome and operationalized as the average of the z-scores of measures of learning and memory, word fluency, and processing speed. Stress measures included self-report assessments of stress appraisal (perceived and acculturative stress) and exposure to chronic and traumatic stressors. MetS was defined via established criteria including waist circumference, high blood pressure, elevated triglycerides, fasting plasma glucose, and high HDL-cholesterol. Systemic inflammation was represented by high sensitivity C-reactive protein (hs-CRP).
RESULTS: Separate survey multivariable linear regression models adjusting for covariates, showed that higher perceived (b=-0.004, SE=0.002, p<.05) and acculturative stress (b=-0.004, SE=0.001, p<.0001) were significantly associated with worse global neurocognition, while lifetime exposure to traumatic stressors was associated with better global neurocognition (b=0.034, SE=0.009, p<.001). Neither MetS or hs-CRP were notable pathways in the association between stress and neurocognition; rather, they were both independently associated with worse neurocognition in models including stress measures (ps< .05).
DISCUSSION: These cross-sectional analyses suggest that stress appraisal, MetS and systemic inflammation may be targets to reduce neurocognitive dysfunction among Hispanics/Latinos.

URL

http://dx.doi.org/10.1093/geronb/gbab150

Reference Type

Journal Article

Year Published

Online ahead of print

Journal Title

Journals of Gerontology Series B: Psychological Sciences and Social Sciences

Author(s)

Marquine, María J.
Gallo, Linda C.
Tarraf, Wassim
Wu, Benson
Moore, Alison A.
Vásquez, Priscilla M.
Talavera, Gregory
Allison, Matthew
Muñoz, Elizabeth
Isasi, Carmen R.
Perreira, Krista M.
Bigornia, Sherman J.
Daviglus, Martha
Estrella, Mayra L.
Zeng, Donglin
González, Hector M.

Article Type

Regular

PMCID

PMC Journal - In Process

Data Set/Study

Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Hispanic/Latinx

ORCiD

Perreira - 0000-0003-2906-0261