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Dietary Vitamin A and Breast Cancer Risk in Black Women: The African American Breast Cancer Epidemiology and Risk (AMBER) Consortium

Citation

Bitsie, Kevin R.; Cheng, Ting-Yuan David; McCann, Susan E.; Zirpoli, Gary R.; Yao, Song; Bandera, Elisa V.; Kolonel, Laurence N.; Rosenberg, Lynn A.; Olshan, Andrew F.; & Palmer, Julie R., et al. (Online ahead of print). Dietary Vitamin A and Breast Cancer Risk in Black Women: The African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. Journal of Nutrition.

Abstract

BACKGROUND: Studies in women of European descent showed an inverse association of dietary vitamin A (retinol and carotenoids) intake with breast cancer risks, mainly in premenopausal women.
OBJECTIVES: We examined whether higher compared with lower levels of dietary vitamin A are associated with reduced breast cancer risks among Black women by estrogen receptor (ER) and menopausal statuses.
METHODS: In this pooled analysis, data were from 3564 breast cancer cases and 11,843 controls (mean ages = 56.4 and 56.3 years, respectively) in the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. Dietary intake was assessed by FFQs. Multivariable logistic regressions were performed to estimate ORs and 95% CIs for study-specific quintiles of total vitamin A equivalents and individual carotenoids, and a pooled OR was estimated by a random-effect model.
RESULTS: We observed an inverse association of total vitamin A equivalents with ER-positive breast cancer (quintiles 5 compared with 1: pooled OR: 0.82; 95% CI: 0.67-1.00; P-trend = 0.045). The association was seen among premenopausal women (pooled OR: 0.60; 95% CI: 0.43-0.83; P-trend = 0.004), but not among postmenopausal women (pooled OR: 0.99; 95% CI: 0.77-1.28; P-trend = 0.78). Additionally, there were inverse associations of dietary β-carotene (quintiles 5 compared with 1: pooled OR: 0.70; 95% CI: 0.51-0.95; P-trend = 0.08) and lutein (pooled OR: 0.63; 95% CI: 0.45-0.87; P-trend = 0.020) with ER-positive breast cancer among premenopausal women. There was no evidence for an association of total vitamin A equivalents or individual carotenoids with ER-negative breast cancer, regardless of menopausal status.
CONCLUSIONS: Our findings on dietary vitamin A and breast cancer risks in Black women are consistent with observations in women of European descent and advance the literature showing an inverse association for ER-positive disease.

URL

http://dx.doi.org/10.1093/jn/nxab278

Reference Type

Journal Article

Year Published

Online ahead of print

Journal Title

Journal of Nutrition

Author(s)

Bitsie, Kevin R.
Cheng, Ting-Yuan David
McCann, Susan E.
Zirpoli, Gary R.
Yao, Song
Bandera, Elisa V.
Kolonel, Laurence N.
Rosenberg, Lynn A.
Olshan, Andrew F.
Palmer, Julie R.
Ambrosone, Christine B.

Article Type

Regular

Data Set/Study

African American Breast Cancer Epidemiology and Risk (AMBER) Consortium

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Black
African-American

Sex/Gender

Ciswomen

ORCiD

Olshan - 0000-0001-9115-5128