Citation
Kim, Daeeun; Howard, Annie Green; Blanco, Estela; Burrows, Raquel A.; Correa-Burrows, Paulina; Memili, Aylin; Albala, Cecilia; Santos, José L.; Angel, Bárbara; & Lozoff, Betsy, et al. (2022). Dynamic Relationships between Body Fat and Circulating Adipokine Levels from Adolescence to Young Adulthood: The Santiago Longitudinal Study. Nutrition, Metabolism & Cardiovascular Diseases, 32(4), 1055-1063. PMCID: PMC9107379Abstract
BACKGROUND AND AIMS: Adipose tissue secretes adipokines such as adiponectin and leptin, playing important roles in energy metabolism. The longitudinal associations between such adipokines and body fat accumulation have not been established, especially during adolescence and young adulthood and in diverse populations. The study aims to assess the longitudinal association between body fat measured with dual X-ray absorptiometry and plasma adipokines from adolescence to young adulthood.METHODS AND RESULTS: Among Hispanic/Latino participants (N = 537) aged 16.8 (SD: 0.3) years of the Santiago Longitudinal Study, we implemented structural equation modeling to estimate the sex-specific associations between adiposity (body fat percent (BF%) and proportion of trunk fat (PTF)) and adipokines (adiponectin and leptin levels) during adolescence (16 y) and these values after 6 years of follow-up (22 y). In addition, we further investigated whether the associations differed by baseline insulin resistance (IR) status. We found evidence for associations between 16 y BF% and 22 y leptin levels (
URL
http://dx.doi.org/10.1016/j.numecd.2022.01.001Reference Type
Journal ArticleYear Published
2022Journal Title
Nutrition, Metabolism & Cardiovascular DiseasesAuthor(s)
Kim, DaeeunHoward, Annie Green
Blanco, Estela
Burrows, Raquel A.
Correa-Burrows, Paulina
Memili, Aylin
Albala, Cecilia
Santos, José L.
Angel, Bárbara
Lozoff, Betsy
Justice, Anne E.
Gordon-Larsen, Penny
Gahagan, Sheila
North, Kari E.
Article Type
RegularPMCID
PMC9107379Data Set/Study
Santiago Longitudinal StudyContinent/Country
ChileORCiD
Howard, AG - 0000-0003-0837-8166Gordon-Larsen - 0000-0001-5322-4188